| Author/Editor | Poljak, Mario; Meško, Karmen M; Seme, Katja | |
| Title | Virusne okužbe pri imunsko oslabljenih bolnikih | |
| Translated title | Viral infections in the immunocompromised patients | |
| Type | članek | |
| Source | Med Razgl | |
| Vol. and No. | Letnik 43, št. Suppl 5 | |
| Publication year | 2004 | |
| Volume | str. 75-80 | |
| Language | eng | |
| Abstract | Herpesviruses are the most important viral pathogens that cause serious infections in immunocompromised patients mostly due to their ability to establish latent, nonproductive infections which can be reactivated at later times resulting in recurrent infections and associated diseases. While improvements in immunosuppressive drug regimens have reduced the risk of organ rejection, they have not restored the immune competence necessary for the control of primary or reactivated herpesvirus infections. This failure has been offset to a significant degree by the advent of improved techniques for viral diagnosis and monitoring and the development of new, potent antiviral drugs for the prophylaxis and treatment of herpesvirus infections. | |
| Summary | Herpesvirusi so zaradi njihove sposobnosti povzročanja latentnih neproduktivnih okužb, ki se lahko kadarkoli reaktivirajo, najpomembnejši virusni povzročitelji težkih okužb pri imunsko oslabljenih bolnikih. Izboljšano imunosupresivno zdravljenje je zmanjšalo pogostost zavrnitve presadkov, vendar je zaradi tega zdravljenja onemogočen učinkovit nadzor primarnih in ponavljajočih se herpesvirusnih okužb. Navedeno pomanjkljivost imunosupresivnega zdravljenja danes odpravljamo z boljšimi metodami odkrivanja virusnih okužb in natančnejšim spremljanjem njihovega poteka ter s pomočjo novih učinkovitih protivirusnih zdravil za preprečevanjein zdravljenje herpesvirusnih okužb. | |
| Descriptors | VIRUS DISEASES IMMUNOCOMPROMISED HOST ORGAN TRANSPLANTATION TRANSPLANTATION IMMUNOLOGY HEMATOPOIETIC STEM CELL TRANSPLANTATION HERPESVIRIDAE INFECTIONS GRAFT REJECTION CYTOMEGALOVIRUS INFECTIONS HERPESVIRUS 1, HUMAN HERPESVIRUS 2, HUMAN HERPESVIRUS 6, HUMAN HERPESVIRUS 7, HUMAN HERPESVIRUS 4, HUMAN HERPESVIRUS 3, HUMAN |