Author/Editor		Hof, Herbert
Title		Fungal and parasitic infections in the immunocompromised host
Translated title		Okužbe z glivami in paraziti pri imunsko oslabljenih bolnikih
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 43, št. Suppl 5
Publication year		2004
Volume		str. 89-96
Language		eng
Abstract		Numerous fungi are present in the environment. Most of them are completely non-pathogenic. Only very few are pathogenic for non-immunocompromised individuals. But a certain number (mainly Candida spp., Aspergillus spp. and Cryptococcus) are able to infect at least immunocompromised patients, although these opportunists do not dispose of a large number of virulence factors. Some other environmental fungi such as Fusarium spp., dematious fungi and zygomycetes are emerging pathogens. In the last few decades, a constant increase in incidence can be observed. In most instances, the invasive infection triggers a serious disease with a very bad prognosis unless a specific therapy is administered. Today, there are new and promising drugs available. A question that is still open is whether they should be applied even prophylactically and in combination.
Summary		V našem okolju so prisotne številne glive. Večina jih je za človeka nenevarnih, nekaj pa jih je patogenih in lahko pri ljudeh z oslabljenim imunskim sistemom povzročijo okužbo. Mednje sodijo predvsem glive vrst Candida spp., Aspergillus spp. in Cryptococcus spp.). Te vrste gliv nimajo velikega števila virulenčnih dejavnikov, kljub temu pa so zmožne okužiti predvsem imunsko oslabljene bolnike. Glive vrste Fusarium spp., nadalje povzročiteljice feohifomikoz (Dematiacee), in zigomicete so mikrobi, ki postajajo vse bolj pomembni patogeni. V zadnjih desetletjih opažamo neprestano naraščanje obolelosti s to vrste gliv. Okužbe se pogosto močno razširijo in nastane resno obolenje, ki ima slabo prognozo, posebno če zdravljenje ni ustrezno. Četudi imamo danes na razpolago nova in obetajoča zdravila, se poraja vprašanje, ali jih je primerno uporabljati profilaktično in v kombinaciji z drugimi.
Descriptors		IMMUNOCOMPROMISED HOST MYCOSES PARASITIC DISEASES HEMATOPOIETIC STEM CELL TRANSPLANTATION CYTOMEGALOVIRUS INFECTIONS HERPESVIRIDAE INFECTIONS CRYPTOCOCCOSIS CANDIDIASIS ASPERGILLOSIS