Author/Editor		Serša, Gregor
Title		Elektroporacija - vnosni sistem za različne molekule
Translated title		Electroporation - a novel antitumor drug delivery system
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 43, št. Suppl 5
Publication year		2004
Volume		str. 149-52
Language		slo
Abstract		Electroporation is a drug delivery system for various molecules into the cells, predominantly for the molecules that have hampered or no transport through the plasma membrane. Electroporation is widely used in vitro, however it is also possible to introduce molecules into the tissues in vivo. Introduced can be either chemotherapeutic drugs or naked DNA, into the tissues like muscle or tumors. Depending on the molecules used the treatment approach is either electrochemotherapy or electrogene therapy. Electrochemotherapy effectiveness has already been demonstrated in clinical trials in cancer patients, and now it is being introduced into the clinical practice with preparation of Standard Operating Procedures - SOP. Thanks to so advanced stage of electrochemotherapy, it is possible now to promote transfer of electrogene therapy from preclinical level into the clinics.
Summary		Elektroporacija je vnosni sistem za različne molekule v celice, ki težko prehajajo celično membrano. Uporablja se lahko v in vitro sistemu, možno pa jo je uporabiti tudi kot vnosni sistem in vivo. In vivo lahko z elektroporacijo vnašamo v različna tkiva, kot so mišice ali tumorji, kemoterapevtike ali golo DNA. Glede na vrsto vnesenih molekul se terapiji imenujeta elektrokemoterapija in elektrogenska terapija. Elektrokemoterapija je danes že prešla faze kliničnih študij in se uvaja v klinično prakso s pripravo standardnih delovnih postopkov (angl. Standard Operating Procedures - SOP). Po zaslugi uvajanja elektrokemoterapije je prenos znanja iz predklinike v kliniko lahko hitrejši tudi v elektrogenski terapiji.
Descriptors		NEOPLASMS ANTINEOPLASTIC AGENTS DRUG DELIVERY SYSTEMS ELECTROPORATION