Author/Editor		Škoberne, Mojca
Title		Apoptotične celice in vpliv na imunski odziv
Translated title		Immunomodulatory role of apoptitic cells
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 43, št. Suppl 5
Publication year		2004
Volume		str. 173-6
Language		slo
Abstract		Over the past few years, evidence has accumulated indicating that clearance of apoptotic cells by phagocytes such as macrophages and dendritic cells can result in anti-inflammatory and immunosuppressive effects. Uptake of apoptotic cells by phagocytes involves several receptors and several among them have been implied to mediate inhibitory effects on dendritic cell maturation and to lead to potentially tolerogenic signals. We speculate that only discrete receptor ligation will modulate the outcome of apoptotic cell uptake at the phagocyte level and the resulting stimulation of effector T cells.
Summary		Fagocitne celice, predvsem makrofagi in dendritične celice, učinkovito odstranjujejo apoptotsko umirajoče celice. Stik med fagociti in apoptotičnimi celicami lahko sproži prorivnetni odziv, ima zavirajoče učinke na razvoj imunosti in sodeluje pri vzdrževanju tolerance do lastnih antigenov. Pri fagocitozi apoptotičnih celic sodeluje veliko receptorjev, vendar domnevamo, da le nekateri od njih prispevajo k zaviranju zorenja dendritičnih celic in posledično k spremenjenemu odzivu limfocitov T.
Descriptors		DENDRITIC CELLS PHAGOCYTES APOPTOSIS ADJUVANTS, IMMUNOLOGIC BIOTIN