Author/Editor		Salobir, Barbara; Terčelj-Zorman, Marjeta; Janša, Rado; Cerar, Anton; Wraber, Branka
Title		Adverse food reaction and nutritive allergy - a study of 25 consecutive patients with an overview of the clinical problem
Type		članek
Source		Gastroenterolog
Vol. and No.		Letnik 8, št. Suppl 2
Publication year		2004
Volume		str. 116-20
Language		eng
Abstract		Background: adverse food reaction (AFR) may be due to toxicity, food intolerance or allergy, the latter being a result of immune mechanisms. AFR is rarer than generally perceived but increasing in frequency. Hypersensitivity responses to food ingestion are of 4 types: I. IgE mediated reaction; II. Antigen-antibody dependent cytotoxic reaction; III. Antigen-antibody complex mediated reaction; IV Cell-mediated reaction. Whereas allergic reactions have been studied extensively in respiratory tract and skin, little is known about the intestinal hypersensitivity reaction. Patients and methods: 25 consecutive pts with suspected nutritive allergy, 39 ± 17 years, 13 male, 12 female; examined clinically, with endoscopy, metacholine test, skin prick test, IgE total and food specific. Results: atopic constitution was confirmed in 17 of 25 pts, food specific IgE were positive in 6. 9 of the other had enteritis, 2 of the other had dermatitis and oral syndrome. All men with AFR enteritis were atopic (N = 8), while 7 of 11 such women were not and almost all had isolated AF enteritis (N = 5 out of 7). Conelusion: isolated gastrointestinal disorders were most of the caused by non-IgE mediated reactions and more often affected women.
Descriptors		FOOD HYPERSENSITIVITY IGE SKIN TESTS ASTHMA GASTROENTERITIS BRONCHIAL PROVOCATION TESTS