Author/Editor		Skitek, M; Piskar, M; Černe, D
Title		Analitični cilji v laboratorijski hematologiji
Translated title		Analytical goals in laboratory haematology
Type		članek
Source		Farm Vestn
Vol. and No.		Letnik 43, št. 3
Publication year		1992
Volume		str. 203-10
Language		slo
Abstract		The authors give a review of development of analytical goals in laboratory haematology. Goals for reproducibility have been set using the methods based on reference values, opinions of clinicians and individuals, the state of analytical systems (the state of the art) and data on biological interindividual variation. The last approach is the most popular since data on biological variation is available for complete blood count. Desirable reproducibility is equal to or less than than onehalf (international recognized goal) or according National Committee for Clinical Laboratory Standards (NCCLS) proposed standard less or equal than one-quarter of the biological within-subject variation. The goal for inaccuracy is very clear. The methods should have no bias. Analytical goals for reproducibility based on biological variation should be therefore viewed and used as goals for total error. In recent study of internal quality control in our laboratory which currently uses the Coulter STKS system (Coulter Electronics, Inc.: Hialeh, Florida) the goals according international recognized goal were attained for assays of leukocyte, erythrocyte and platelet count, hemoglobin concentration, mean erythrocyte volume, haematocrit and mean cell haemoglobin, but not yet attained for mean cell haemoglobin concentration. Analytical goals according NCCLS proposed standard were attained for assays of leukocyte and erythrocyte count, hemoglobin concentration and mean erythrocyte volume, but not yet attained for platelet count.
Descriptors		HEMATOLOGIC TESTS REFERENCE VALUES QUALITY CONTROL REFERENCE STANDARDS