Author/Editor		Starovasnik, Barbara; Sever, Alenka
Title		Motnje kognitivnih sposobnosti pri bolnikih s Parkinsonovo boleznijo
Translated title		Cognitive impairments in patients with the Parkinsons disease
Type		članek
Source		Psihol Obz Ljubl
Vol. and No.		Letnik 13, št. 2
Publication year		2004
Volume		str. 83-90
Language		slo
Abstract		As the motor disturbances are the most well known, easily observed and the only ones used in the diagnosis of the Parkinsons disease (PD), the non-motor features of the PD are often overlooked even though the cognitive impairments in the area of direction and sustenance of attention, working memory and other executive functions present a most disabling effect on the ability to cope with everyday life tasks. There is no reason to assume that the degeneration in PD and its effect are limited to motor loop only, but could affect the rest of the cortico-subcortico-cortical loops as well, resulting in specific cognitive dysfunctions related to individual »cognitive« loops. Specifically the impairment of dorsolateral loop should lead to dysfunction of working memory and other executive abilities, the impairment of orbitofrontal loop typically results in lack of social control, obsessive and compulsive behavior, emotional instability and impulsiveness, while anterior cingulate loop is related to dysfunctions of attention and consequent decreased motivation and lack of interest.
Summary		Iz znanstvenih teoretičnih konceptov lahko izpostavimo trditev, da Parkinsonova bolezen poleg motoričnega sistema opazno oškoduje tudi kognitivne procese in z njimi povezane sposobnosti bolnika. Ugotovljeno je namreč, da degeneracija dopaminskih nevronov ni omejena zgolj na motorično zanko in zato prizadene deloma tudi ostale t.i. kortiko - subkortiko kortikalne zanke, ki posledično povzročajo kognitivne motnje, poleg tega pa verjetno še motnje čustvovanja, kot je depresija. Nemoteno delovanje dopaminergičnega nevrotransmiterskega sistema lahko namreč povežemo s splošno kognitivno storilnostjo ter obsegom in načinom delovanja delovnega spomina (dorzolateralna zanka), specifičnih kognitivnih operacij, povezanih predvsem z delovanjem pozornostnega sistema ter generalnega izvršitvenega sistema človeka (anteriorna cingulna zanka), v tem primeru bolnika s Parkinsonovo boleznijo.
Descriptors		PARKINSON DISEASE COGNITION DISORDERS BASAL GANGLIA NEURAL PATHWAYS DOPAMINE COGNITION