Author/Editor		Šuput, Dušan; Ribarič, Samo
Title		Liver cell damage and serum enzymes
Type		članek
Source		In: Ferlan-Marolt V, Luzar B, editors. Viral hepatitis. Proceedings of the 35th memorial meeting to professor Janez Plečnik with international participation; 2004 Dec 2-3; Ljubljana. Ljubljana: Faculty of medicine, Institute of pathology,
Publication year		2004
Volume		str. 49-54
Language		eng
Abstract		Hepatocytes affected respond to different noxious agents such as toxicants or microbes in a similar way, but the time course and the final outcome may differ significantly depending on the causative agent and the time of its action. Acute and chronic liver failure are therefore characterized by different clinical and biochemical features. Hepatitis C virus (HCV) is a serious world-wide spread disease, which results in chronic liver degeneration and in liver cancer. Recently a link between the HCV infection and Hodgkin lymphoma has also been described. Although the available tests enable a straightforward diagnosis of viral hepatitis, the pathogenesis of acute and chronic liver failure is still not clear. The aim of this paper is to present a short overview of hepatocyte function in health and disease, to give an outline of possible mechanisms involved in a virus-induced hepatocyte failure, and to point out some developments in understanding the role of virus-host interactions in the pathogenesis of HCV.
Descriptors		LIVER FAILURE LIVER FUNCTION TESTS ALANINE AMINOTRANSFERASE ASPARTATE AMINOTRANSFERASE ALKALINE PHOSPHATASE 5'-NUCLEOTIDASE METABOLIC DETOXICATION, DRUG BILIRUBIN SERUM ALBUMIN HEPATITIS C