Author/Editor		Rott, Tomaž; Ferluga, Dušan
Title		Exsanguination from the ruptured nodule of the hepatocellular carcinoma, developed in cirrhotic liver after hepatitis B viral infection - 14 years follow-up of the patient
Type		članek
Source		In: Ferlan-Marolt V, Luzar B, editors. Viral hepatitis. Proceedings of the 35th memorial meeting to professor Janez Plečnik with international participation; 2004 Dec 2-3; Ljubljana. Ljubljana: Faculty of medicine, Institute of pathology,
Publication year		2004
Volume		str. 181-3
Language		eng
Abstract		Backgronnd. Hepatitis B virus (HBV) infection has an important role in the development of chronic hepatitis, liver cirrhosis and even hepatocellular carcinoma. The aim of presentation. The follow-up of the patient enabled observation of hepatitis B virus infection, which gradually developed to hepatocellular carcinoma with fatal outcome. Presentation of the patient. The 49-years old male patient is presented, probably infected by hepatitis B virus during his work as autopsy assistant. During the period of 14years, the evolution of no-progressive persistent infection to progressive chronic viral hepatitis B, and later to liver cirrhosis with hepatocellular carcinoma was followed, based upon the findings of 5 successive liver biopsies and autopsy after fatal outcome of disease. The autopsy revealed fatal intra-abdominal exsanguination from the ruptured nodule of hepatocellular carcinoma, developed in cirrhotic liver. Conclusion. Infection with hepatitis B virus may gradually develop from different stages of chronic liver disease to hepatocellular carcinoma. It remains the primary risk factor for the development of hepatocellular carcinoma all over of the world.
Descriptors		HEPATITIS B LIVER CIRRHOSIS LIVER NEOPLASMS CARCINOMA, HEPATOCELLULAR MIDDLE AGE BIOPSY AUTOPSY