Author/Editor		Markovič, Saša
Title		Disease recurrence after liver transplantation due to viral hepatitis
Type		članek
Source		In: Ferlan-Marolt V, Luzar B, editors. Viral hepatitis. Proceedings of the 35th memorial meeting to professor Janez Plečnik with international participation; 2004 Dec 2-3; Ljubljana. Ljubljana: Faculty of medicine, Institute of pathology,
Publication year		2004
Volume		str. 284-9
Language		eng
Abstract		Recurrence of viral hepatitis in liver graft is a frequent problem. Immunosuppression by modulation of the immune response plays an important role in recurrence and the progression of the disease in livergraft. Recurrence of hepatitis C is nearly universal. At year 3 post-transplant 80% of patients have histologic evidence of recurrent chronic hepatitis C. Progressive graft injury leading to cirrhosis occurs in 5 years in up to 35% of patients and 10% of patients will eventually need re-transplantation. Treatment of recurrent graft hepatitis C is disappointing. In contrast, hepatitis B recurrence can be effectively prevented by the use of combination of HBlg and lamivudine. Recurrent hepatitis B appears when vaccine escape mutant or lamivudine resistant mutants appear The treatment is successful with combination of lamivudine or adefovir dipivoxil, or adefovir alone.
Descriptors		HEPATITIS C HEPATITIS B LIVER TRANSPLANTATION CHOLESTASIS RECURRENCE DISEASE PROGRESSION