Author/Editor		Hočevar, Alojzija
Title		Pomen ultrazvočne preiskave obušesnih in podčeljustnih žlez slinavk v diagnostiki primarnega Sjoegrenovega sindroma
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2004
Volume		str. 59
Language		slo
Abstract		Primary Sjogren's syndrome (PSS) is the second most common, chronic systemic autoimmune disease, characterized by progressive inflammatory destruction of exocrine glands. The dysfunction of lachrymal and salivary glands, leading to symptoms and objective findings of keratoconjunctivitis sicca and xerostomia is the key clinical manifestation and the mainstay for the diagnosis of PSS. In the past three decades many criteria sets for diagnosing PSS have been introduced as a result of still unknown disease's etiopathogenesis and absence of single, enough specific test to form the basis of diagnosis. Despite recently published classification criteria, proposed by American-European Consensus group in year 2002 (which serve also as diagnostic criteria) the assessment of salivary gland involvement in PSS is still a matter of debate. In addition to accepted tests, namely unstimulated salivary flow test (USF), salivary gland scintigraphy and sialography other methods for confirmation of salivary gland affection are beeing studied. Among them ultrasonography (US) of major salivary glands as noninvasive and nonradiating investigation seems attractive. However in past only few studies evaluated the role of salivary gland US in diagnosing PSS. We aimed to determine with our crossectional study the US salivary glands' parameters that discriminate between PSS and non PSS, and the significance of ultrasonography in the diagnosing PSS. In 218 consecutive patients with suspected PSS, US of both parotid and submandibular salivary glands was performed besides the regular diagnostic procedure following the European criteria proposed by the American-European Consensus Group in year 2002. Five US parameters were semiquantitatively assessed: echogeneity, inhomogeneity, clearness of salivary gland borders, number of hypoechogenic areals, hyperechogenic reflections. (Abstract truncated at 2000 characters).
Descriptors		SJOGREN'S SYNDROME PAROTID GLAND SUBMANDIBULAR GLAND XEROPHTHALMIA XEROSTOMIA SALIVARY GLANDS, MINOR ANTIBODIES, ANTINUCLEAR SALIVATION BIOPSY ROC CURVE