Author/Editor		Jeras, Matjaž
Title		Vpliv tkivne (ne)skladnosti pri transplantaciji krvotvornih matičnih celic iz popkovnične krvi
Type		članek
Source		In: Bricl I, Lampreht N, editors. Transfuzijska medicina v porodništvu. Zbornik strokovnih prispevkov 6. podiplomski seminar Zdravljenje s krvjo; 2004 dec 3-4; Portorož. Ljubljana: Zavod Republike Slovenije za transfuzijsko medicino,
Publication year		2004
Volume		str. 119-27
Language		slo
Abstract		In recent years, umbilical cord blood (UCB) has emerged as a possible and feasible alternative source of hematopoietic stem cells (HSC) for allogeneic transplantation, mainly in patients who lack HLA-matched related and unrelated donors. Among more than 3500 transplanted patients since the first reported case in 1989, the vast majority of recipients are children. However, up to now, more than 500 UCB transplantations were performed in adults as well. The naive state of UCB lymphocytes T permits the use of grafts with 1 (5/6) or 2 (4/6) HLA antigen or allele mismatches with the same risk of generating graft versus host disease as in the case of HLA compatible allogeneic bone marrow transplantation. The main disadvantage of UCB is, that it contains low numbers of stem cells, resulting in higher rates of graft failure as well as problems related to delayed time to engraftment as compared to allogeneic bone marrow transplantation. A possible approach to overcome this important limitation involves different ways of in vitro cultivation and expansion of UCB derived hematopoietic stem cell precursors. Nowadays this kind of HSC enrichment and a concomitant use of two different UCB units have made the UCB transplantation more and more accessible to adult patients as well.
Descriptors		PLACENTA BLOOD HEMATOPOIETIC STEM CELLS HEMATOPOIETIC STEM CELL TRANSPLANTATION HISTOCOMPATIBILITY TESTING GRAFT VS HOST REACTION HLA ANTIGENS