Author/Editor		Jurečič, Ana; Benedik, Janez; Marn-Skok, Sonja
Title		Postoperative nausea and vomiting at major otolaryngologic surgery and efficacy of granisetron
Type		članek
Source		In: Della-Rocca G, Giordano F, editors. Proceedings of the 17th anesthesia and ICU symposium "Alpe Adria"; 2004 Sep 24-25: Udine. Udine: University of Udine, Department of anesthesia and ICU,
Publication year		2004
Volume		str. 90-4
Language		eng
Abstract		Introduction: Postoperative nausea and vomiting (PONV) continues to be a common complication of surgery with higher risk in major otolaryngologic surgery. The aim of our pilot study was to evaluate this potential risk and efficacy of granisetron. In the second part of the study, relevance of application of the questionnaire for evaluation of the risk for developing PONV was also tested. Methods: In the prospective, randomised pilot study, we observed 20 patients, ASA 13, that were scheduled for major otolaryngologic surgery. They were randomly devided into two groups, granisetron (N=10) and placebo (N=10) group. 5 minutes before induction of anaesthesia, granisetron 1 mg was given as an i.v. injection over 30 seconds to ganisetron group. Anaesthesia was in both groups with isoflurane, nitrous oxide, fentanyl and vecuronium. Patients were assesed 24 hours after operation for incidence of nausea, vomiting or both. To those who experienced PONV, a rescue antiemetic was given. In the second part of the study, the questionnaire for evaluation of the risk for developing PONV was applied to 9 patients, ASA 1-3, that were scheduled for major otolaryngologic surgery. For each patient, the questionnaire was filled out and points were added up. If the sum was 7 or more, granisetron 1 mg i.v. as a prophylactic antiemetic was given before surgery. The same postoperative assesment was for these patients as for the first part of the study. Results: In the first part of the study 20% (2/10) of patients experienced PONV in the placebo group, whereas no patient experienced PONV in the granisetron group. Both patients who experienced PONV in placebo group received granisetron as a rescue antiemetic, no interventions were necessary afrer that. In the second part of the study, 66,6% (6/9) did not receive granisetron (sum was 7 or less) and 33,3% (3/9) of patients did (sum of more than 7). In the granisetron group 1 patient experienced nausea. (Abstract trunacted at 2000 characters).
Descriptors		POSTOPERATIVE COMPLICATIONS NAUSEA VOMITING GRANISETRON LARYNGEAL NEOPLASMS QUESTIONNAIRES