| Author/Editor | Uležić-Paučič, Danijela | |
| Title | Poraba koncentriranih eritrocitov in skladnost krvnih skupin AB0 med darovalcem in prejemnikom po alogenični sorodniški presaditvi krvotvornih matičnih celic | |
| Type | monografija | |
| Place | Maribor | |
| Publisher | Splošna bolnišnica Maribor | |
| Publication year | 2004 | |
| Volume | str. 30 | |
| Language | slo | |
| Abstract | Background. Primitive lymphohematopoietic stem cells do not express blood group antigens. Thus, AB0 incompatibility does not preclude allogeneic hematopoietic stem cell transplantation (HSCT). HSCT across AB0-mismatch barriers carries additional risks, e.g. immune hemolysis, delayed erythroid engraftment and persistence of isohemagglutinins. Methods. I have analyzed retrospectively transfusion requirements [the number of red blood cells (RBC) components] in the third months after allogeneic-related HSCT. Data from 57 consecutive pairs of related donors and HLA-matched recipients with hematologic malignancies undergoing HSCT between 1989 and 1999 were reviewed. Based on donor/recipient AB0 compatibility, transplant pairs were subdivided into three groups: group with AB0 identical pairs, group with major mismatch (including major, and bidirectional major and minor mismatch) and group with minor mismatch. Standard statistical methods were used to compare variables between groups (chi-square, Pearson's correlation analysis, ttest, median value). Results and conclusions. Diagnosis, age and sex of recipients, age and sex of donors, sexmismatch and sex-compatibility between donor and recipient pairs and female sex of donors did not influence transfusion requirements. Development of acute graft-versus-host-disease (aGVHD) in all patients was associated with increased transfusion requirements (r = 0.432, p = 0.0012). An increased transfusion requirements was associated with minor AB0 mismatch between donor and recipient vs AB0 compatible group of patients (p =.025). | |
| Descriptors | HEMATOPOIETIC STEM CELL TRANSPLANTATION BLOOD GROUPING AND CROSSMATCHING ABO BLOOD-GROUP SYSTEM BLOOD DONORS ERYTHROCYTE TRANSFUSION GRAFT VS HOST DISEASE SEX FACTORS RETROSPECTIVE STUDIES |