Author/Editor		Kravos, Alenka
Title		Vloga alergije pri nastanku Reinkejeva edema glasilk
Type		monografija
Place		Ljubljana
Publisher		Univerza v Ljubljani, Medicinska fakulteta
Publication year		2004
Volume		str. 63
Language		slo
Abstract		Background: Reinke's oedema (RE) is a hyper-plastic epithelial lesion of vocal cords that causes hoarseness. Vocal cords are swollen on free border and upper surface, because of enlargement of Reinke's space, which is situated under the epithelium of vocal cord mucosa. In Reinke's space intercellular fluid and amorphic substance that are composed of glycoprotein fibronectin and proteoglicans are accumulated. Capillaries are enlarged, endothelium thin, fenestrae in walls of the vessels are enlarged. Vulnerability of the vessels during mechanical stress of the vocal cords and enlarged permeability of vessel walls are direct causes for RE. Etiology of RE is still not completely clear. Among possible factors for development of RE are those that irritate mucosa of the larynx, causing inflammation or those that increase mechanical stress of vocal cords. Since the majority of patients are smokers, epidemiological studies have confirmed connection between RE and smoking. Numerous authors stress the importance of excessive and incorrect voice production in etiology of RE. Among possible reasons for collection of oedema in Reinke's space are hormonal disturbances, gastrooesophageal regurgitation to the level of hypopharynx and larynx, exposure to unfavourable microclimatic conditions at work, at home and allergy. Identifying allergic reaction of type I as a probable cause for development of RE appeared more than 20 years ago, but results of the first rare surveys on that issue were not published until past few years. Goals of survev: The goal of our survey was to establish the frequency of allergic reaction of type I in patients with RE and its importance for development of RE. We also wanted to establish the presence of other known factors important for development of RE on vocal cords. (Abstract truncated at 2000 characters).
Descriptors		HOARSENESS VOCAL CORDS LARYNGOSCOPY SKIN TESTS RHINITIS, ALLERGIC, PERENNIAL THYROID DISEASES SMOKING GASTROESOPHAGEAL REFLUX MICROCLIMATE PROSPECTIVE STUDIES THYROTROPIN