Author/Editor		Lindič, Jelka
Title		Morfologija parietalnega peritoneja pri uremičnih bolnikih
Type		monografija
Place		Ljubljana
Publisher		Univerza v Ljubljani, Medicinska fakulteta
Publication year		2004
Volume		str. 81
Language		slo
Abstract		Peritoneal dialysis is one of substitute methods for the treatment of patients with terminal renal failure. Since it is performed by the patient at home, and the patient is able to do all of his/her usual everyday work while undergoing dialysis, this type of dialysis is named continuous ambulatory peritoneal dialysis (CAPD). In terms of its effects and the patients' quality of life, it has become comparable to treatment with hemodialysis. By using this method, the patient is able to exchange the dialysis solution in the abdomen several times a day via a peritoneal catheter that is inserted into the abdominal cavity through the abdominal wall. In this method, the peritoneal membrane functions as a substitute or artificial kidney, because uremic toxins, electrolytes, minerals and water are eliminated from the body through this membrane. After many years of treatment, failure of the peritoneal membrane may develop due to chronic inflammatory changes in the peritoneum that is in contact with a bioincompatible dialysis solution, and possibly also as a result of previous peritonitis episodes. For the time being, peritoneal membrane failure cannot be predicted, treated or prevented with sufficient success and in all patients with membrane failure peritoneal dialysis needs to be discontinued. The objective of this study was to confirm a hypothesis that compared to uremic patients without diabetes, those with diabetes exhibit changes in their parietal peritoneum even before the beginning of treatment with peritoneal dialysis. It was assumed that during treatment with CAPD, diabetic patients as well as nondiabetic ones develop histological changes in the parietal peritoneum; these changes are similar to those seen in diabetic patients before peritoneal dialysis, but are more extensive. It is believed that during peritonitis the parietal peritoneum undergoes changes that are characteristic of an acute inflammatory process. (Abstract trunacted at 2000 characters).
Descriptors		UREMIA KIDNEY FAILURE, CHRONIC PERITONEAL DIALYSIS, CONTINUOUS AMBULATORY PERITONEUM PERITONITIS MIDDLE AGE BIOPSY IMMUNOHISTOCHEMISTRY MICROSCOPY, ELECTRON DIABETES MELLITUS