Author/Editor		Maver, Jerica
Title		Študij kožne reaktivne hiperemije z laser-dopplerskim tokomerom
Type		monografija
Place		Ljubljana
Publisher		Univerza v Ljubljani, Medicinska fakulteta
Publication year		1992
Volume		str. 38
Language		slo
Abstract		Finger nailfold skin blood flow was monitored by laser-Doppler (LD) flowmeter in 18 healthy volunteers after the occlusion of digital arteries. The primary aim of the study was to characterize the microcirculatory pattern of postocclusive reactive hyperaemia. LD flowmetry revealed two parts of the hyperaemic response. The first part was characterized by maximum LD flow and large amplitude of the oscillations which correspond to heart beats. The second part was characterized by the appearance of periodic oscillation with fundamental frequency from 0.07 to 0.19 Hz. In order to elucidate the physiological background of this phenomenon, the cutaneous vascular bed was exposed to the changes of transmural pressure, secured by different position of the limb, and to different levels of ischaemia, accomplished by varying the duration of occlusion. Reactive hyperaemia after digital arteries occlusion was also compared to that evoked by the occlusion of brachial artery. It was found that the area under the first part of LD flow increased with prolongation of arterial occlusion. The increment was found to be significant between 1 and 4 (p=0.009) and 4 and 8 (p=0.006) minutes of occlusion. Also, the area proved to be independent of transmural pressure (R=0.06, p=0.74). In contrast, the fundamental frequency of periodic oscillations in the second part of the response proved to be pressure dependent but showed no significant correlation with the duration of arterial occlusion (p < 0.001). We found no significant differences between the parameters of hyperaemic response evoked by occlusion of brachial and digital arteries with the exception of the peak flow time (p < 0.05). It is our conclusion that the first part of LD hyperaemic response reflects predominant contribution of metabolic components in contrast to the periodic oscillations in the second part of the response, which very likely reflect myogenic response. The phenomenon is reproducible regardless of the occlusion site.
Descriptors		FINGERS HYPEREMIA LASER-DOPPLER FLOWMETRY BRACHIAL ARTERY