Author/Editor | Peter, F | |
Title | Children with short stature born small for gestational age - a new indication for treatment with growth hormone | |
Translated title | Otroci z nizko rastjo, rojeni majhni za gestacijsko starost - nova indikacija za zdravljenje z rastnim hormonom | |
Type | članek | |
Source | Slov Pediatr | |
Vol. and No. | Letnik 11, št. 3 | |
Publication year | 2004 | |
Volume | str. 63-47 | |
Language | eng | |
Abstract | In approximately 10% of newborns born small for gestational age the catch-up growth into the normal height range during the first 2-3 years of life does not occur. The majority of these children become short adults. In recent years several studies have been carried out to eliminate this type of short stature. This review article summarizes the international experience in this field. It is emphasized that growth is not the only problem in small for gestational age children. This review concentrates on human growth hormone treatment. Attention is drawn to the main prognostic factors: the starting age, dose and duration of human growth hormone therapy. Further important parameters are the growth and bone age retardation at the start of treatment as well as the target height. Today, an early start, a moderately elevated dose, and long-term (continuous or intermittent) therapy are proposed. In this group, systematic control of carbohydrate metabolism is especially important. Key words: growth hormone therapy, children born small for gestational age. | |
Summary | Pri približno 10% novorojencev, ki so rojeni majhni za gestacijsko starost, ne opažamo nadomestne rasti v prvih 2 - 3 letih življenja in so nizke rasti tudi v odraslosti. Članek zajema pregled področja v mednarodni literaturi, ki prinaša podatke o presnovnih značilnostih teh otrok in o izkušnjah pri zdravljenju z rastnim hormonom v tej skupini. Uspeh zdravljenja je odvisen od starosti otroka, njegove kostne starosti ob začetku zdravljenja, odmerka in trajanja zdravljenja z rastnim hormonom, vzorca rasti in tarčne višine otroka. Najuspešnejše je zdravljenje, ki ga začnemo že zgodaj v otroštvu z zmerno visokimi odmerki in traja dalj časa (prekinjeno ali neprekinjeno). V času zdravljenja z rastnim hormonom moramo kontrolirati presnovo glukoze. | |
Descriptors | DWARFISM, PITUITARY INFANT, SMALL FOR GESTATIONAL AGE GROWTH DISORDERS SOMATOTROPINS, RECOMBINANT INFANT, NEWBORN CHILD PUBERTY TREATMENT OUTCOME |