Author/Editor		Kirbiš, Janez; Milutinović, Aleksandra; Steblovnik, Klemen; Teran, Nataša; Terzić, Rifet; Zorc, Marjeta
Title		The -429 T/C and - 374 T/A gene polymorphisms of the receptor of advanced glycation end products gene (RAGE) are not risk factors for coronary artery disease in Slovene population with type 2 diabetes
Type		članek
Source		Coll Antropol
Vol. and No.		Letnik 28, št. 2
Publication year		2004
Volume		str. 611-6
Language		eng
Abstract		Receptor for advanced glycation end products (RAGE) plays a role in atherosclerosis in diabetics. There are two functional polyrnorphisms in the promoter of the RAGE gene (-429T/C and -374T/A). The aim of this study was to look for a relationship between the -429T/C and the -374T/A gene polymorphisms of the RAGE gene and the development of coronary artery disease (CAD) in the Slovene population with type 2 diabetes of duration longer than 10 years. Orne hundred and sixty-eight subjects with diabetes and CAD were compared to 241 diabetic subjects without CAD. The -429T/C and the -374T/A RAGE genotype distributions in patients with CAD (-429T/C: CC: 3%, TC: 31%, TT: 66.0%; -374T/A: AA: 7.7%, TA: 48.2%, TT: 44.1%) were not significantly different from those in patients without CAD (-429 T/C: CC: 1.7%, TC: 26.1%, TT: 72.2%; -374T/A: AA: 11.2%, TA: 43.2%, TT: 45.6%). Our study failed to demonstrate an association between either the -429T /C or the -374T/A gene polymorphism of the RAGE gene and CAD in the Slovene population with type 2 diabetes of duration longer than 10 years.
Descriptors		DIABETES MELLITUS, NON-INSULIN-DEPENDENT CORONARY DISEASE POLYMORPHISM (GENETICS) GLYCOSYLATION END PRODUCTS, ADVANCED GENOTYPE GLYCOSYLATION PROMOTER REGIONS (GENETICS) ODDS RATIO SLOVENIA