Author/Editor		Zorc-Pleskovič, Ruda; Bidovec, Matjaž; Bregar, Dejan; Milutinović, Aleksandra; Terzić, Rifet; Teran, Nataša
Title		The ScaI gene polymorphism of the atrial nutriuretic factor and essential arterial hypertension in childhood
Type		članek
Source		Coll Antropol
Vol. and No.		Letnik 28, št. 2
Publication year		2004
Volume		str. 617-21
Language		slo
Abstract		In order to investigate the contribution of the atrial natriuretic factor (ANF) gene in pathogeraesis of essential arterial hypertension (EAH), we analyzed the Scal gene polymorphism of the ANF gene in a group of children with EAH. Fifty-eight children, aged 8-19 years, with the diagnosis of EAH were included in the association study and were compared to 57 subjects with normal blood pressure (the control group). Arterial hypertension was defined as systolic/diastolic blood pressure higher than the 95th age-gender-height percentile of the adopted reference values. We failed to demonstrate an association between the Scal ANF gene polymorphism and EAH in childhood (OR=2; 95% CI 0.9-4.2; p=0.07), however we provided evidence of an interaction between the Scal ANF gene polymorphism and obesity defined as BMI over the 85th percentile (OR=13.1; 95% CI 1.6-106; p<0.001).
Descriptors		HYPERTENSION ATRIAL NATRIURETIC FACTOR POLYMORPHISM (GENETICS) GENOTYPE CHILD ADOLESCENCE BLOOD PRESSURE AGE FACTORS BODY WEIGHT BODY HEIGHT BODY MASS INDEX