Author/Editor		Besednjak-Kocijančič, Lilijana
Title		Povezava med zgornjim uvajanjem jajčnega rumenjaka v otrokovo prehrano in pojavom atopijskega dermatitisa v starosti 18 mesecev
Translated title		Relationship between early exposure to egg yolk and atopic dermatitis in 18 months old children
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 74, št. 1
Publication year		2005
Volume		str. 23-6
Language		slo
Abstract		Background. Atopic eczema/dermatitis syndrome (AEDS) is the most frequent inflammatory disease of the skin in the childhood. A cause-effect link between food allergy and atopic dermatitis (AD) has been established and sensitization to hen's egg is considered a strong predictor for AD. Egg yolk is usually introduced into the child's diet in the first year. The purpose of this study was to assess the influence of early introduction of egg yolk into the diet on AD prevalence in 18 month old children. Methods. 269 infants with birth weight at least 3000 g and with a positive history ofparental allergy confirmed by allergy testing were included. They were divided in three groups according their age at the introduction of boiled egg into the child's diet: group A - children eating egg yolk from 6 month; group B - children eating egg yolk from month; group C children eating egg yolk from 12 month. Children from all groups were exclusively breast fed for at least 6 month while their mothers were on a diet without eggs. The diagnosis of AD was made according to the criteria of Hanifin and Rajka. At 18 months of age sensitization to egg yolk was evaluated with specific IgE testing and skin prick test (SPT). Statistical analysis was performed with SPSS 10.0 using the Mantel-Haenszel chi-square test. Results. In group A 57.1%, group B 31.7% and in group C 21.3% of children developed AEDS (p < 0.0001). Elevated serum total IgE had 58.9% of children from group A, 34.1% from group B and 18.7% from group C (p < 0.0001). Elevated specific IgE antibodies to egg yolk had 25.0% of children from group A, 12.2% from B and 6.7% from C (p = 0. 001). Positive SPT with egg yolk had in group A 37.5%, B 23.1% and C 18.7% of children with AD (p = 0. 099). Conclusions. We demonstrated a negative influence of early introduction of egg yolk into the diet on AD and AEDS prevalence in a group of newborns at risk for atopic diseases.
Summary		Izhodišča. Atopijski ekcem/dermatitis sindrom (AEDS) je najpogostejša vnetna bolezen kože pri otrocih. Dokazana je povezava med senzibilizacijo na alergene hrane in atopijskim dermatitisom (AD). Alergiji na jajce pa se pripisuje visoka napovedna vrednost za razvoj AD pri otroku. Pogosto se uvede rumenjak v otrokovo prehrano že v prvem letu starosti. Namen raziskave je bil ugotoviti, kako vpliva zgodnja vpeljava jajčnega rumenjaka v prehrano na prevalenco AD pri 18-mesečnih otrocih. Metode. V prospektivno raziskavo je bilo vključenih 269 novorojencev s porodno težo nad 3000 g in potrjeno alergijo pri starših. Glede na starost ob uvedbi rumenjaka so bili otroci razdeljeni v tri skupine: A - rumenjak v prehrani od 6 meseca, B - od 9. meseca in C - od 12. meseca dalje. Vsi so bili izključno dojeni 6 mesecev. Doječe matere so bile na dieti brez živil iz jajc. Diagnoza AD je bila v skladu z diagnostičnimi merili za AD po Hanifinu in Rajki. V starosti 18 mesecev smo ugotavljali senzibilizacijo na rumenjak s kožnim testiranjem po Pricku (SPT) in z določanjem specifičnih IgE protiteles. Mantel-Haenszel hi2 test je bil uporabljen za potrditev razlike v prevalenci AEDS/AD med skupinami. Podatki so bili obdelani na PC v programski aplikaciji SPSS 10.0. Rezultati. AEDS je imelo 57,1% otrok iz skupine A, 31,7% otrok iz skupine B in 21,3% otrok iz skupine C (p < 0,0001). Zvišana celotna serumska IgE protitelesa je imelo v skupini A 58,9%, v B 34,1% in v C 18,7% otrok (p < 0,0001). Povišana specifična IgE protitelesa na jajčni rumenjak pa je imelo 25,0% otrok iz skupine A, 12,2% iz B in 6,7% iz skupine C (p = 0,001). Pozitiven SPT test z alergeni jajčnega rumenjaka je imelo v skupini A 37,5%, v B 23,1% in v C 18,7% otrok z AD (p = 0,099). Zaključki. Raziskava potrjuje neugoden vpliv zgodnjega uvajanja jajčnega rumenjaka v otrokovo prehrano na pojav AD in AEDS pri družinsko obremenjenih otrocih.
Descriptors		INFANT NUTRITION EGG YOLK DERMATITIS, ATOPIC SKIN TESTS IGE FOOD HYPERSENSITIVITY PROSPECTIVE STUDIES INFANT