Author/Editor		Cankar, K; Finderle, Ž; Štrucl, M
Title		The role of alpha1- and alpha2-adrenoreceptors in gender differences in cutaneous LD flux response to local cooling
Type		članek
Source		Microvasc Res
Vol. and No.		Letnik 68
Publication year		2004
Volume		str. 126-31
Language		eng
Abstract		The present study was designed to assess the hypothesis Ihat alpha2-adrenergic response plays a predominant role in sex differences in cutaneous microvascular response to cold. For this purpose, we studied the effect of the selective alpha2-antagonist prazosin 1 microl of 1.2 mM solution) and the alpha2-antagonist yohimbine (1 microl of 12 mM solution) microinjected into the skin area where the laser-Doppler (LD) flux response to local cooling was measured in healthy male and female subjects. Multiple regression analysis showed correlation between LD flux response at the site of local cooling (direct response) and gender (F = 0.039). The LD flux decrease was smaller in males. The applicalion of the yohimbine significantly diminishod the LD flux response at tho site of local cooling in temales but not in males (P < 0.05). In contrast, the injection of prazosin did not significantly affect the response. These findings strongly support the suggestion of a decisive role of alpha2-adrenoceptors in cold-induced gender difference at the level of cutaneous microvasculature at the site of local cooling. Multiple regression analysis of LD flux response to cold exposure at the site distant to cooling (indirect response) also confirmed correlation between LD flux response and gender (P = 0.022). The LD flux deerease was smaller in males. The alpha1-antagonist abolished the LD flux response to cold exposare (P = 0.000). These results corroborate the importance of alpha1-adrenoceptors in skin microcirculatory response to indireet local cooling mediated by the sympathetic vascular reflex.
Descriptors		SKIN MICROCIRCULATION FINGERS LASER-DOPPLER FLOWMETRY COLD ADULT PRAZOSIN YOHIMBINE RECEPTORS, ADRENERGIC, ALPHA ANALYSIS OF VARIANCE