Author/Editor		Zorec-Karlovšek, M
Title		Postmortem diagnosis of diabetes mellitus and diabetic coma: a comparison of HBA1, glucose, lactate, and combined glucose and lactate values in vitreous humour and in cerebrospinal fluid
Type		članek
Source		In: Jacob B, Bonte W, editors. Advances in forensic sciences: forensic criminalistics 2 (vol 4). Proceedings of the 13th meeting of the international association of forensic sciences; 1993 Aug 22-28; Duesseldorf. Berlin: Verlag Dr. Koester,
Publication year		1993
Volume		str. 38-48
Language		eng
Abstract		HbA1 in blood, glucose, lactate and the combined glucose and lactate levels in vitreous humour and in cerebrospinal fluid were examined in 41 autopsy cases with diabetes and 71 cases in a control group. The mean levels of hbAI, glucose and the combined glucose and lactate levels in vitreous humour and in cerebrospinal tluid showed statistically significant differences between the diabetic and control groups. Postmortem glucose levels in vitreous humour were statistically significantly higher than in cerebrospinal fluid; the average lactate levels were significantly higher in cerebrospinal fluid than in corpus vitreum in both groups. As a result there were no statistically significant differences between the combined glucose and lactate levels in vitreous humour and in cerebrospinal fluid in the control group. The calculated 99% threshold values for the right-hand tail of the glucose-lactate concentration curve in the control group were 427 mg/dl and 422 mg/dl for vitreous humour and cerebrospinal fluid respectively. To avoid the use of conventional units (mg/dl, mg%) for the threshold values, a new graphical representation in the form of a lactate - glucose diagram is introduced. The calculated regression coefficients in the correlation study led to the conclusion that postmortem-determined hbA 1 and the parameters (glucose and combined glucose and lactate levels) in vitreous humour provide the best information on the pre-mortal glycemie of the diabetic group in all parameters studied.
Descriptors		FORENSIC MEDICINE AUTOPSY DIABETES MELLITUS DIABETIC COMA HEMOGLOBIN A, GLYCOSYLATED BLOOD GLUCOSE LACTATES GLUCOSE VITREOUS BODY