| Author/Editor | Crnjac, Anton | |
| Title | Vpliv pH plevralnega izliva na uspešnost torakoskopske mehanske plevrodeze pri bolnicah s karcinomom dojke | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Medicinska fakulteta | |
| Publication year | 2005 | |
| Volume | str. 76 | |
| Language | slo | |
| Abstract | Malignant pleural effusion is a frequent and serious complication of the breast carcinoma which causes the patients respiratory problems because of the pressure to the lung, chronic cough and pain and therefore significantly reduces the quality of their remaining life. Numerous more or less aggressive palliative methods for the treatment of the effusion are used in current practice. The most frequent among them is chemical pleurodesis with talcum, which is insufficiently effective when the pH of the malignant pleural effusion is bellow 7.3, due to tumour infiltration or fibrosis of the pleura. In the prospective randomized study, we compared the efficiency of the treatment of the malignant pleural effusion of the breast carcinoma with thoracoscopic mechanical pleurodesis as a new palliative method and the chemical pleurodesis with talcum, taking into consideration different values of the pH of the pleural effusion. The purpose of our research was to discover whether the changed pH values of the malignant pleural effusion influence the efficiency of the treatment with thoracoscopic mechanical pleurodesis and to determine which is the lowest pH value still ensuring the efficiency of those two palliative methods. The basic research hypothesis was that at lower pH values thoracoscopic mechanical pleurodesis is a more successful palliative method of treating malignant pleural effusion than chemical pleurodesis with talcum. Eigthy-seven patients with the breast carcinoma and consequent malignant pleural effusion resistant to systemic therapy were divided into two groups. (Abstract truncated at 2000 characters) | |
| Descriptors | BREAST NEOPLASMS PLEURODESIS THORACOSCOPY PLEURAL EFFUSION, MALIGNANT HYDROGEN-ION CONCENTRATION PALLIATIVE CARE TREATMENT OUTCOME SURVIVAL ANALYSIS |