Author/Editor		Zaletel, Marjan
Title		Analiza živčno-žilne sklopitve pri bolnikih z migreno
Translated title		Analysis of neurovascular coupling in migraneours
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 74, št. 2
Publication year		2005
Volume		str. 83-8
Language		slo
Abstract		Background. According to recent data it is not clear whether neurovascular coupling is disturbed in migraneours during headache free period. The aim of our study was to establish whether the relationship between visually evoked cerebral blood flow responses (VEFR) and visual evoked potentials (VEP) is changed in migraneours during headache free period. Methods. The records were made from 30 healthy volunteers and 30 migraine patients. The mean arterial velocity in the left middle cerebral artery and the mean arterial velocity in rightposterior cerebral artery were monitored by using transcranial Doppler ultrasound. The VEP were recorded from occipital leads. Neuronal activity was changed by changing visual contrast. Results. We found that significant and moderate relationship between the vEP and the VEFR (r = 0. 66; p < 0. 01) in healthy subjects and in migraneours as well (r = 0.63; p < 0.01). The difference between the regression slopes of the healthy subjects (b = 0.55) and the patients with migraine (b = 0.88) was significant (p = 0. 04). Conclusions. We concluded that neurovascular coupling in migraneours during headache free period is more active than in healthy subjects.
Summary		Izhodišča. Iz dosedanjih študij ni znano, ali je živčno žilna sklopitev pri bolnikih z migreno v času brez migrenskih napadov spremenjena. Zato smo v študiji skušali ugotoviti, ali se povezava med vidnimi evociranimi možganskimi odgovori krvnega pretoka (VEOP) in vidnimi evociranimi potenciali (VEP) razlikuje od povezave pri zdravih preiskovancih. Metode. v raziskavo smo vključili 30 zdravih preiskovancev in 30 bolnikov z migreno. Srednjo arterijsko hitrost v levi srednji možganski arteriji in desni zadnji možganski arteriji smo merili z ultrazvočno transkranialno doplersko preiskavo. VEP smo izmerili iz zatilnih odvodov. Električno nevronsko aktivnost smo spreminjali s spreminjanjem vidnega kontrasta. Rezultati. vEP in VEOP so bili tako pri zdravih preiskovancih (r = 0, 66; p < 0, 01) kot pri bolnih z migreno (r = 0, 63; p < 0, 01) zmerno statistično pomembno povezani. Naklon regresijske premice je bil pri bolnikih z migreno b = 0, 88 (SE = 0, 07) in pri zdravih preiskovacih b = 0,55 (SE = 0, 08). Razlika med naklonoma je bila statistično pomembna (p = 0, 04). Zaključki. Na temelju rezultatov smo zaključili, da je živčnožilna sklopitev pri bolnikih z migreno v času brez napadov aktivnejša kot pri zdravih preiskovancih.
Descriptors		MIGRAINE EVOKED POTENTIALS, VISUAL CEREBRAL ARTERIES BLOOD FLOW VELOCITY ULTRASONOGRAPHY, DOPPLER, TRANSCRANIAL CONTRAST SENSITIVITY