Author/Editor		Šorli, J; Grassino, A; Lorange, G; Milič-Emili, J
Title		Control of breathing in patients with chronic obstructive lung disease
Type		članek
Source		Clin Sci Mol Med
Vol. and No.		Letnik 54, št. 3
Publication year		1978
Volume		str. 295-304
Language		eng
Abstract		1. Using the mouth occlusion pressure technique, we have studied the control of breathing in seven hypercapnic and eight non-hypercapnic patients with chronic obstructive lung disease. 2. When breathing room air, pulmonary ventilation, mean inspiratory flow and P0.1 (mouth occlusion pressure developed 0.1 s after the onset of occluded inspiration at functional residual capacity) were not significantly different between the two groups of patients. Tidal volume, however, was significantly lower in the hypercapnic than in the non-hypercapnic patients, as a result of a significantly lower duration of inspiration. 3. The lower tidal volume in the hypercapnic patients leads to decreased alveolar ventilation, and appears to be the main cause of retention of carbon dioxide.
Descriptors		LUNG DISEASES, OBSTRUCTIVE RESPIRATION LUNG LUNG VOLUME MEASUREMENTS HYPERCAPNIA MIDDLE AGE AGED