Author/Editor		Koković, Ira; Bračko, Matej; Golouh, Rastko; Ligtenberg, Marjolijn; van Krieken, Han JJM; Hundler, Petra; Komel, Radovan
Title		Are there geographical differences in the frequency of SYT-SSX1 and SYT-SSX2 chimeric transcripts in synovial sarcoma?
Type		članek
Source		Cancer Detect Prev
Vol. and No.		Letnik 28, št. 4
Publication year		2004
Volume		str. 294-301
Language		eng
Abstract		Synovial sarcoma (SS) is characterized by the t(X;18)(p11.2;q11.2) chromosomal translocation, which results in generating either SYTSSXI, SYT-SSX2 or, infrequently, SYT-SSX4 fusion gene. The ratio of SYT-SSXI:SYT-SSX2 fusions is close to 2:1 in the majority of studies, and SYT-SSX2 fusion has been only rarely observed in biphasic SS. In the present study, we compared two series of patients with SS, Slovenian (37 cases) and Dutch (14 cases), with respect to clinical, pathological and molecular findings. The two groups did not differ with regard to clinicopathological features. Whereas the frequency of different SYT-SSX fusions in the Dutch group was similar to that reported in the literature, we found an unexpectedly high number of tumors with SYT-SSX2 fusion in the Slovenian group. The ratio of SYT-SSXI:SYT-SSX? fusion was 7:18 for monophasic and 2:7 for biphasic tumors in the Slovenian group. This distribution differs significantly from that observed in the Dutch group in the present study (P = 0.041) as well as from data reported in the recent large multi-institutional study on 243 patients (P = 0.0001). Our findings indicate possible geographical differences in the frequency of two SYT-SSX fusion transcripts in patients with synovial sarcoma.
Descriptors		SARCOMA, SYNOVIAL TRANSLOCATION (GENETICS) POLYMERASE CHAIN REACTION SURVIVAL ANALYSIS SLOVENIA NETHERLANDS