Author/Editor		Šuput, Dušan
Title		Effects of microcystins on rat and human hepatocytes
Type		članek
Source		In: Goudey-Perriere F, Benoit E, Puiseux-Dao S, et al, editors. Envenimations, intoxinations.. Paris: Societe Francaise pour l'etude des toxines (SFET),
Publication year		2004
Volume		str. 53-62
Language		eng
Abstract		Microcystins, produced by common planktonic species of freshwater cyanobacteria, constitute a risk to human health. Hence, microcystin intoxication leads to gastric problems, severe liver damage and extensive intrahepatic hemorrhage, and even death of patients. Although many reports in the literature show that microcystins affect human health, very few studies have been done on cells of human origin. Because of interspecies variations in the metabolism and susceptibility of cells to different agents, only the use of human cells can give appropriate results if human toxicology is considered. Here, a comparative study of the effects of microcystin LR (MCLR) on the primary culture of human and rat hepatocytes is presented. Primary human hepatocytes were more susceptible to MCLR toxicity than rat cells. Considering also the data reported by several authors indicating tumor promoting effects of long term exposure to microcystins in several highly populated regions, it must 6e emphasized that high safety measures must be taken in monitoring the quality of water used in human nutrition and medical care.
Descriptors		FRESH WATER CYANOBACTERIA BACTERIAL TOXINS LIVER RATS CELLS, CULTURED OXIDATIVE STRESS APOPTOSIS DNA DAMAGE