Author/Editor     Martinčič, David
Title     Preprečevanje ekscitotoksične poškodbe striatuma poskusne podgane z isradipinom
Type     monografija
Place     Ljubljana
Publisher     Univerza v Ljubljani, Medicinska fakulteta
Publication year     2004
Volume     str. 40
Language     slo
Abstract     INTRODUCTION Excitotoxic brain injury contributes to the development of neurodegenerative changes in numerous neurologic diseases (stroke, epilepsy, Parkinson's and Alzheimer's disease). Excitotoxicity is the result of the excessive endogenous release of excitatory neurotransmitter glutamate and excitotoxine quinolinic acid (QA), while in brain nuclei that contain a high concentration of dopamine (e.g. striatum), excessive release of dopamine may be a contributing factor. Due to the central role of neuronal Ca++ concentration for the development of excitotoxic injury, MK801, that prevents the entry of Ca++ trough the channel of NMDA receptor, prevents the development of excitotoxicity. The clinical use of MK801 is unfortunately hampered by its psychosomimetic activity. Isradipine, an antagonist of voltage dependent L-type Ca++ channels, may also be capable of preventing excitotoxic injury by its ability to antagonize the release of neurotransmitters. Although isradipine is already used in clinical preactice as an effective antihipertensive, there are only a few data in the literature regarding its neuroprotective potential. AIMS Using the rat model of unilateral stereotaxic intrastriatal injection of QA we aimed to investigate 1) if isradipine, similar to MK801, could prevent striatal and hippocampal edema and the development of hemiepileptic seiyures of the contralateral size 2) if isradipine could reduce the neurodegenerative changes of the striatum induced by QA. HYPOTHESIS We have hypothesized, that similarly to the effects of MK-801, isradipine could prevent the QA-induced effects of excitotoxic striatal injury. (Abstract truncated at 2000 characters).
Descriptors     CORPUS STRIATUM
ISRADIPINE
EXOCYTOSIS
QUINOLINIC ACID
CYTOCHROME-C OXIDASE
EPILEPSY
MAGNETIC RESONANCE IMAGING
DENSITOMETRY
BEHAVIOR, ANIMAL
HIPPOCAMPUS
CALCIUM CHANNEL BLOCKERS
RATS, WISTAR