Author/Editor     Perše, Martina; Cerar, Anton
Title     The dimethylhydrazine induced colorectal tumours in rat - experimental colorectal carcinogenesis
Translated title     Z dimetilhidrazinom inducirani tumorji debelega črevesa in danke pri podgani
Type     članek
Source     Radiol Oncol
Vol. and No.     Letnik 39, št. 1
Publication year     2005
Volume     str. 61-70
Language     eng
Abstract     Animal models of colorectal carcinogenesis represent invaluable research tool for investigating colorectal cancer (CRC). Experimentally induced tumours in laboratory animals provide opportunity for studying certain aspects of tumours that cannot be effectively studied in humans. Significant information on human CRC aetiology or factors influencing it has derived from studies using dimethylhydrazine (DMH) model that is one of the experimental models appreciated for its morphological similarity to human CRC. Today, DMH model represents useful research tool for the studies of colon carcinogens and chemopreventive agents. The review offers insight into morphogenesis and genetic alterations of DMH induced colorectal epithelial tumours in rats.
Summary     Živalski modeli so pri raziskavah raka na debelem črevesju in danki nepogrešljivi, saj omogočajo raziskovanje in testiranje številnih dejavnikov, ki jih ni mogoče neposredno ugotavljati pri ljudeh. Edinega izmed živalskih modelov raka na debelem črevesju in danki predstavljajo z dimetilhidrazinom (DMH) inducirane podgane, ki razvijejo tumorje debelega črevesa in danke zelo podobne humanim. S člankom želimo predstaviti morfološke in genetske spremembe tega modela, ki je veliko prispeval k današnjemu poznavanju etioloških in drugih dejavnikov, ki vplivajo na nastanek in razvoj raka. Danes pa je nepogrešljiv pri raziskavah črevesnih karcinogenov in kemopreventivnih substanc.
Descriptors     COLORECTAL NEOPLASMS
DIMETHYLHYDRAZINES
ADENOMA
ADENOCARCINOMA
DISEASE MODELS, ANIMAL
RATS, INBRED F344
RATS, SPRAGUE-DAWLEY
RATS, WISTAR