Author/Editor		Boras, Ivana; Sprogar, Špela
Title		Vpliv endotelinskega sistema na ortodontske premike zob pri podganah
Type		monografija
Place		Ljubljana
Publisher		Univerza v Ljubljani, Medicinska fakulteta
Publication year		2004
Volume		str. 45
Language		slo
Abstract		BACKGROUND Tooth movement occurs if an adequate force is applied. Many chemical messengers are released which interfere with the remolding of bone and periodontal ligament of the tooth. One of the chemical messengers present in the periodontal ligament in physiological conditions is endothelin. Axial loading of a tooth causes a rise of the endothelin expression. The role of endothelin in the process of tooth movement has not been explained yet. Therefore we will try to explain the role of the endothelin system in orthodontic tooth movement in rats using tezosentan, a competitive dual (non sejective) endothelin receptor antagonist. AIM. The aim of the study is to determine the effects of tezosentan on tooth movement in rats. This will explain the role of the endothelin system in orthodontic tooth movement. HYPOTHESIS. Knowing the effects of endothelin on blood vessels and bone metabolism, we suspected that the tooth movement in rats treated daily with tezosentan will be greater compared to the appliance group. METHODS. The studie was performed on male Wistar rats divided into 3 groups (n=7). The first group was applied a tractive coil spring and was daily treated with tezosentan. The second group was also applied a tracitve coil spring but was not treated with tezosentan. The appliance was placed on the upper left first molar and the upper incisors. Third group performed as control group and was not given anything. We measured the distances between the upper molars and incisors on both sides to determine tooth movement using a digitronic caliper (precision 0,01 mm). Measurements were made on days 0, 7, 14, 21 and 25 of the study. We used GraphPad Prism 4.00 and one way Anova for statistical analysis. RESULTS. The distance between the upper molars and the incisors decreased in all appliance groups. (Abstract truncated at 2000 characters).
Descriptors		ORTHODONTIC APPLIANCES TRACTION MOLAR INCISOR TOOTH MOVEMENT RECEPTORS, ENDOTHELIN BLOOD PRESSURE ANALYSIS OF VARIANCE RATS, WISTAR