Author/Editor		Žele, Tilen
Title		Vpliv staranja na kolateralno brstenje senzoričnih aksonov po poškodbi perifernega živca pri podgani
Type		monografija
Place		Ljubljana
Publisher		Univerza v Ljubljani, Medicinska fakulteta
Publication year		2004
Volume		str. 42
Language		slo
Abstract		BACKGROUND. Aging reduces the extent of collateral sprouting of uninjured motor and sympathetic axons after the peripheral nerve injury. Possible age related differences regarding the collateral sprouting of uninjured sensory axons are not known. AIM. To study possible age related differences regarding the extent of collateral sprouting of uninjured sensory axons into denervated areas of skin and into end-to-side nerve anastomosis. HYPOTHESES. l. Collateral sprouting of uninjured sensory axons into adjacent denervated areas of skin is less extensive in older than in younger rats. 2. Collateral sprouting of uninjured sensory axons into the end-to-side nerve anastomosis is less extensive in older than in young rats. 3. The recovery of sensory function of skin due to collateral sprouting of uninjured sensory axons through the end-to-side nerve anastomosis is less extensive in old than in young rats. 4. Less extensive collateral sprouting of sensory axons in aged animals is not due to a lower number of myelinated axons in donor nerves of the old animals. METHODS. In the first experiment, the recovery of skin sensitivity in instep due to collateral sprouting of uninjured sural nerve axons after permanent transection of other nerves was monitored using skin pinch test in groups of young adult, middle aged and aged rats. In the second experiment, the extent of collateral sprouting of sensory axons into endto-side anastomosed nerve segment in groups of young adult, middle aged and aged rats was evaluated with histological analysis 8 weeks after the operation. In addition we histologically analyzed donor and untreated kontralateral sural nerve. In the third experiment, we monitored recovery of skin sensitivity in instep after end-to-side anastomosis of the distal segment of the injured nerve to untreated sural nerve. (Abstract truncated at 2000 characters).
Descriptors		SURAL NERVE PERONEAL NERVE NERVE REGENERATION AXONS NOCICEPTORS PAIN THRESHOLD SKIN AGE FACTORS RATS, WISTAR