| Author/Editor | Goličnik, Alenka; Ferjan, Mateja | |
| Title | Vpliv atorvastatina na trajanje intervala QTC pri bolnikih s srčnim popuščanjem | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Univerza v Ljubljani, Medicinska fakulteta | |
| Publication year | 2004 | |
| Volume | str. 40 | |
| Language | slo | |
| Abstract | BACKGROUND. Heart failure is a clinical condition in which the heart is not able to deliver oxygen and nutrients to peripheral tissues at normal filling pressures. QT interval is defined as time measured from the beginning of the QRS complex to the end of the T wave. It reflects the depolarization and repolarization times of the ventricles. The progression of heart failure is related to QT interval prolongation. In patients with heart failure, QT interval longer than 440ms is a strong predictor of pump failure and sudden cardiac death. Furthermore, patients with heart failure often display changes in QRS complex duration, which reflect alterations of depolarization time of the ventricles. QRS complex of more than 120 ms represents a sign of delayed electrical conduction of the heart. Recently, elevated plasma level of pro brain natriuretc peptide (proBNP) is being recognized as an important predictor of outcome in heart failure patients. AfMS. Inhibitors of 3-hydroxy-3-methylglutaryl CoA (FIMG-CoA) reductase - statins are the most commonly used therapy in hypercholesterlemic patients. Recently, several studies have shown that statins may improve general condition and outcome in patients with heart failure. These positive effects of statins do not appear to be related to their ability to lower cholesterol levels in blood. The aim of our study was to define the potential effects of atorvastatin on QTc interval duration in patients with heart failure. We also investigated the possible associations of statin therapy and some other prognostic parameters in heart failure (duration of QRS complex, 6-minute walk test, proBNP plasma levels). (Abstract truncated at 2000 characters). | |
| Descriptors | HEART FAILURE, CONGESTIVE HYPERCHOLESTEROLEMIA ANTILIPEMIC AGENTS ELECTROCARDIOGRAPHY NATRIURETIC HORMONE EXERCISE TEST CASE-CONTROL STUDIES |