Author/Editor		Štrumbelj, Iztok; Ribič, Helena; Franko-Kancler, Tatjana; Božanić, Vinko; Grmek-Košnik, Irena; Sarjanović, Ljudmila; Kavčič, Martina; Harlander, Tatjana
Title		Odpornost izolatov Streptococcus pneumoniae iz dihal v letu 2003
Translated title		Antimicrobial resistance in Streptococcus pneumoniae isolates in 2003
Type		članek
Source		Zdrav Vars
Vol. and No.		Letnik 44, št. 2
Publication year		2005
Volume		str. 80-4
Language		slo
Abstract		Objective: To determine resistance to selected antibiotics in respiratory tract isolates of Streptococcus pneumoniae in year 2003. Methods: From January to December 2003, 879 S. pneumonia isolates from the respiratory tract collected in eight microbiology laboratories in Slovenia were studied for their susceptibility to several antimicrobials and for the phenotype of resistance to macrolides. Results: All the isolates tested were susceptible to vancomycin, levofloxacin and moxifloxacin; 16.6% of strains were intermediately resistant and 0.5% were resistant to penicillin. Intermediate resistance to cefotaxim was established in 0.2% of strains, and resistance in 0%. The rate of resistance to trimethoprim-sulfamethoxazole was 27%, to tetracycline 12.2%, to erythromycin 12.3% and to clindamycin 9.8%. Considerable differences in the rate of resistance to some antibiotics were found between the regions studied. Conclusions: The established rates of resistance to the antimicrobials tested provide the basis for appropriate choice of antibiotic therapy. There were no significant differences in resistance rates between the year 2003 and the previous two years.
Summary		Namen: Pri izolatih iz dihal iz leta 2003 ugotoviti delež odpornih izolatov vrste Streptococcus pneumoniae proti nekaterim antibiotikom. Metode: V osmih slovenskih mikrobioloških laboratorijih so v letu 2003 iz dihal osamili 879 izolatov vrste Streptococcus pneumoniae. Pri izolatih so določili občutljivost za izbrane antibiotike in fenotip odpornosti proti makrolidom. Rezultati: Vsi testirani izolati so bili občutljivi za vankomicin, levofloksacin in moksifloksacin. Proti penicilinu je bilo 16,6% vmesno odpornih in 0,5% odpornih izolatov, proti cefotaksimu je bilo 0,2% vmesno odpornih izolatov, odpornih ni bilo. Delež odpornosti proti trimetoprim-sulfametoksazolu je bil 27%, proti tetraciklinu 12,2%, proti eritromicinu 12,3% in proti klindamicinu 9,8%. Pri nekaterih antibiotikih so bile razlike med regijami precejšnje. Zaključek: Ugotovljeni deleži odpornih izolatov so dobra osnova za racionalno izbiro antibiotičnega zdravljenja. V primerjavi z letoma 2001 in 2002 v letu 2003 ni bilo velikih razlik.
Descriptors		RESPIRATORY TRACT INFECTIONS STREPTOCOCCUS PNEUMONIAE DRUG RESISTANCE, MICROBIAL