Author/Editor		Urlep-Žužej, Darja
Title		Pomen, uporabnost in diagnostična vrednost neinvazivnih diagnostičnih metod kronične vnetne črevesne bolezni v pediatriji
Type		monografija
Place		Ljubljana
Publisher		Univerza v Ljubljani, Medicinska fakulteta
Publication year		2005
Volume		str. 90
Language		slo
Abstract		Inflammatory bowel disease (IBD) is known to be a chronic disorder with one of the most serious courses of illness in children and adolescents. The prevalence of the disease is constantly increasing in the childhood and adolescent periods. It is of great importance for growing children and adolescents that the disease is recognised and treated in the early stages when treatment is far more effective and serious complications of the disease like growth deceleration with short stature, pubertal delay, stenosis and fistulas of the bowel can be prevented. Among children, the diagnosis of IBD -particulary Chron's disease- is often missed or delayed because of the nonspecific nature of both the intestinal and extraintestinal symptoms. The intestinal symptoms of IBD overlap with functional bowel disorders such as recurrent abdominal pain and irritable bowel syndrome in childhood. In other cases, joint pains, pubertal delay and short stature may be the clinical presentation of IBD, in the absence of any digestive signs or symptoms. This obligates clinicians to exclude IBD using invasive diagnostic testing, in particular, colonoscopy with biopses. In order to asses the most important symptoms and signs of the clinical presentation of IBD and the most important haematological and biocemical laboratory tests in distinguishing IBD from functional and other bowel disorders (with suspected clinical preseritation of IBD) we compared two groups of patients - a group of 49 children and adolescents with confirmed IBD and a group of 53 children and adolescents with functional and other bowel disorders with suspected clinical presentation of IBD (control group). The colonoscopy with biopses was performed in all of our patients from both groups to confirm or exclude IBD. (Abstract truncated at 2000 characters).
Descriptors		INFLAMMATORY BOWEL DISEASES COLONOSCOPY ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC SACCHAROMYCES CEREVISIAE ANTIBODIES, FUNGAL CHILD ADOLESCENCE MUTATION BIOPSY CROHN DISEASE COLITIS, ULCERATIVE