Author/Editor		Gorišek-Miksić, Nina
Title		Vpliv različnih dejavnikov na nastanek metabolnega sindroma z lipodistrofijo pri slovenskih bolnikih, okuženih s HIV
Type		monografija
Place		Ljubljana
Publisher		Univerza v Ljubljani, Medicinska fakulteta
Publication year		2005
Volume		str. 62
Language		slo
Abstract		Backgroud: The introduction of highly active antiretroviral therapy (HAART) has made a major advance in treatment of HIV patients. However, this therapy is related to the development of metabolic syndrome (MS) and lipodystrophy (LD). Pathogenesis of MS is not well understood. Inhibition of adipogenesis and insulin resistance seem to play a central role. Many factors have been associated with MS, specially duration of HAART therapy, the use of protease inhibitors (PI) and nucleoside analogue reverse transcriptase inhibitors (NRTI). Other factors could be involved in the pathogenesis of MS beside the antiretroviral therapy, such as immune system, hormonal influences and HIV infection per se. We estimated the prevalence of MS among Slovenian HIV infected patients treated with HAART and assessed the influence of different parameters on development of MS. . Patients and methods: We studied a group of 3G HIV infected patients treated with HAART for at least 2 years and a control group of 14 HIV infected patients naive to antiretroviral therapy. The prevalence of MS was estimated by checking the medical records, using self-reporting questionnaires and clinical examination according to the criteria presented by Carr and collegues. Patients were devided in three groups: treated group with MS (MS+), treated group without MS (MS-) and the control group of HAART naive patients (HAART-). For each patient we have taken two stored frozen blood samples; first one from the end of December 2002 (sample number 1) and the second one from the time before the introduction of HAART in MS+ and MS- group and from the time of beginning of infection in HAART- group (sample number 2) and have measured fasting serum levels of insulin, cortisol and tumor necrosis factor a (TNF-alpha). (Abstract truncated at 2000 characters).
Descriptors		HIV INFECTIONS LIPODYSTROPHY ANTI-HIV AGENTS HYPERLIPIDEMIA INSULIN RESISTANCE INSULIN TUMOR NECROSIS FACTOR HYDROCORTISONE CD4 LYMPHOCYTE COUNT ANTILIPEMIC AGENTS VIRAL LOAD RETROSPECTIVE STUDIES