Author/Editor		Mušič, Ema
Title		Inhalation and nutritional allergy and histamine intolerance
Type		članek
Source		In: Proceedings of the 5th F. Kogoj memorial symposium; 2005 Jun 10-11; Ljubljana. Ljubljana: Klinični center, Dermatovenerološka klinika,
Publication year		2005
Volume		str. 102-5
Language		eng
Abstract		Today the concept of systemical involvement of aliergic processes is incontestable even where the clinical manifestation is present in only one organ because immunoresponsive cells interact in several parts of the body. In an atopic type of allergy, the central product of the cell excitation, such as mastocytes and basophilic leukocytes, is histamine. Clinically, an allergy is manifested in particular as the effects of acutely elevated quantities of histamine in different tissues. Most commonly, these processes can be observed in allergies caused by inhalation allergens, nutritional allergens and pseudoallergens as well as in histamine intolerance. Fortunately, there are slightly fewer drug and insect sting allergies yet they are more intensive and dangerous for the development of the most severe forms of anaphylaxis, which is again due to the abundant release of histamine in cases of the atopical mechanism. In addition, histamine also causes symptoms in histamine intolerance where considerable amounts of histamine have entered the body or have developed therein with not enough levels of the enzyme diaminooxidase being available to degrade it. In adults, histamine intolerance is at least 10 times more common than the food allergy with the mechanism of IgE antibodies. All hypersensitive reactions can be divided into immunological and non-immunological ones. The immunological reactions are further subdivided into processes with IgE antibodies and those without them. Histamine intolerance is a non-immunological phenomenon caused by the presence of elevated histamine levels which cannot be dissimilated.
Descriptors		FOOD HYPERSENSITIVITY ALLERGENS HISTAMINE ANAPHYLAXIS ASTHMA RHINITIS, ALLERGIC, PERENNIAL CROSS REACTIONS