Author/Editor		Glaser, Marjana
Title		Plazmocitom - diferencialna diagnoza in zdravljenje
Translated title		Multiple myeloma - differential diagnosis and therapy
Type		članek
Source		In: Hojs R, Krajnc I, Pahor A, et al, editors. Iz prakse za prakso. Zbornik predavanj in praktikum 16. srečanje internistov in zdravnikov splošne medicine z mednarodno udeležbo; 2005 maj 20-21; Maribor. Maribor: Splošna bolnišnica Maribor,
Publication year		2005
Volume		str. 107-17
Language		slo
Abstract		Multiple myeloma or plasmacytoma is an uncurable malignant neoplasm affecting terminally differentiated B cells. Its clinical picture can be very heterogenous, involving monoclonal immunoglobulin overproduction and hematologic, skeletal and renal complications. Diagnosis includes hematologic and skeletal examinations. Treatment consists of chemotherapy, autologous bone marrow transplantation, antiangiogenic medication and recently proteasome inhibitors. Supportive treatment is also required. As new therapeutic agents affecting molecular mechanisms are under investigation, we need to understand the molecular pathogenesis of the disease. The prognosis depends on the rapid identification of the disease and on distinguishing it from other monoclonal diseases. Therefore investigation guidelines available in primary care are presented.
Descriptors		PLASMACYTOMA MULTIPLE MYELOMA DIAGNOSIS, DIFFERENTIAL PARAPROTEINEMIAS