Author/Editor		Zaletel, Marjan; Žvan, Bojana
Title		Testiranje funkcionalne možganskožilne rezerve
Type		članek
Source		In: Blinc A, Kozak M, Šabovič M, editors. Slikovne metode v odkrivanju in zdravljenju žilnih bolezni. Letno srečanje Združenja za žilne bolezni SZD; 2005 maj; Ljubljana. Ljubljana: Združenje za žilne bolezni,
Publication year		2005
Volume		str. 112-23
Language		slo
Abstract		Testing of vasomotor reserve enablesus to establish perfusion state of the brain. For this purpose, we use carbone dioxide as a potent cerebrovascular vasomotor stimulus. The cerebrovascular response can be monitored noninvasively by using transcranial Doppler sonography (TCD). This technique permit nonivasive measurement of arterial velocity in the middle cerebral artery sirnultaneously with continuous measurement of heart rate, arterial pressure and end-tidal carbon dioxide (C02). These signals constitute a multimodal record. In order to induce vasodilatation of cerebral vessels a gas mixture with 6 % CO2 is usually used. Highgrade stenosis of internal carotid artery increases arterial resistance in the carotid vascular territory, which subsequentially induces a decrease in perfusion pressure and cerebral blood flow (CBF). The collateral circulation, mostly through the circle o f Willisi, is important to maintain CBF, when such a condition appears. However, if is insufficient in certain percentage of patients. Furthermore, the condition of decreased CBF can be determined by TCD. It is well known that high stenosis of internal carotid artery is a risk factor for stroke. By testing of vasomotor reserve we can additionaly assess stroke risk among patients with carotid stenosis. Exhausted vasomotor reserve is an independent risk factor for stroke or transient ischemic attack in patients with carotid occlusion or stenosis. Testing of cerebrovascular reactivity to I-arginine can assess the functional state of small cerebral arteries.
Descriptors		CEREBROVASCULAR CIRCULATION CARBON DIOXIDE CEREBRAL ARTERIES BLOOD FLOW VELOCITY VASODILATION ULTRASONOGRAPHY, DOPPLER, TRANSCRANIAL BLOOD PRESSURE HEART RATE ARGININE CAROTID STENOSIS CEREBRAL ISCHEMIA CEREBRAL INFARCTION