Author/Editor		Dolinšek, J; Urlep-Žužej, D; Mičetić-Turk, D
Title		Klinična sika in diagnostika kroničnih vnetnih črevesnih bolezni
Translated title		Clinical picture and diagnosis of inflammatory bowel disease
Type		članek
Source		In: Gregorič A, editor. Otrok s kronično črevesno boleznijo, bolečina pri otroku, zdravstveno varstvo otrok in mladine: organizacija, stroka, denar. Zbornik 15. srečanje pediatrov v Mariboru z mednarodno udeležbo in 2. srečanje medicinskih sester z mednarodno udeležbo; 2005 apr 15-16; Maribor. Maribor: Splošna bolnišnica Maribor,
Publication year		2005
Volume		str. 199-204
Language		slo
Abstract		Inflammatory bowel disease (IBD) in children and adolescents presents itself mainly as ulcerative colitis and Crohn's disease. The precise aetiology and pathogenesis of the disease is not completely understood. The diagnosis of IBD is based on the clinical picture as well as laboratory data, imaging procedures, and endoscopic evaluation with histological examination of biopsy specimens. Ulcerative colitis and Crohn's disease have several distinguishing features. Ulcerative colitis only affects the large intestine, whereas Crohn's disease can affect any part of the digestive tract. The clinical picture is determined by the localization, extent and duration of the disease. Patients with a severe form of the disease always present with systemic signs. Extraintestinal involvement is commonly associated with IBD. The gold standard for the diagnosis of IBD is endoscopic evaluation of the digestive tract with its ability to directly visualize any mucosal changes. Endoscopy also permits multiple biopsies to be obtained for histological evaluation. Imaging procedures, including ultrasound (US), scintigraphy, contrast studies, computerized tomography (CT) and magnetic resonance imaging (MRI) are important in diagnosing IBD. Newer diagnostic procedures in IBD include immunological and genetic testing. Establishing a firm diagnosis of IBD is not only important diagnostically, but also enables the most successful therapy to be selected, and the most appropriate follow-up regime to be determined.
Descriptors		INFLAMMATORY BOWEL DISEASES COLITIS, ULCERATIVE CROHN DISEASE CHILD ADOLESCENCE DIAGNOSIS, DIFFERENTIAL