| Author/Editor | Hlastan-Ribič, Cirila; Cerar, Anton; Pokorn, Dražigost | |
| Title | Učinek kefirja z različno vsebnostjo maščob v hrani poskusnih živali na pojav eksperimentalnih črevesnih tumorjev | |
| Translated title | Effects of kefir with different fat levels on chemically induced colorectal epithelial tumors | |
| Type | članek | |
| Source | In: Bilban M, editor. Cvahtetovi dnevi javnega zdravja 2005; 2005 jun; Ljubljana. Ljubljana: Univerza v Ljubljani, Medicinska fakulteta, | |
| Publication year | 2005 | |
| Volume | str. 113-23 | |
| Language | slo | |
| Abstract | Background: Colorectal carcinoma (CRC) is one of the most frequently observed malignant tumors in the developed countries. The aim of the study was to determine the effect of kefir (with diferent fat levels) and milk on the incidence of experimentally induced colorectal epithelial tumors (CET). Material: We used 120 ten weeks old male Wistar rats. For the induction of intestinal tumors, we used 1.2 -dimethylhydrazine (DMH). The animals were randomly distributed into four groups: three experimental and one control group. First experimental group received kefir containing 3.5% of fat, the second group kefir with 1.1% of fat and the third group milk with 1.1% of fat. Samples for histological evaluation were taken from the whole length of the colon. Results: The kefir 3.5 group had the highest number of adenocarcinomas and the lowest number was found in milk 1.1 group (p=0,048). The lowest number of adenomas was found in the kefir 1.1 group. We found a statistically high correlation between the incidence of adenocarcinomas and the jat intake (P = 0.0338) and a high statistical correlation between the incidence of all forms of CET (aberrant crypt foci (ACF), adenomas and adenocarcinomas) and the intake of fat (P < 0,001). Conclusion: We can conclude that a higher fat ration, can cause a higher incidence of CRC and CET. The results show that the consumption of low fat milk has a protective role against the development of CRC. We didn't prove the protective role of kefir on the development of CRC | |
| Descriptors | COLORECTAL NEOPLASMS DIMETHYLHYDRAZINES MILK RATS, WISTAR |