Author/Editor		Zadnik, Vesna
Title		Evropska raziskava vplivov dejavnikov tveganja na zbolevanje za rakom dojk pri mladih ženskah: (podatki za Slovenijo)
Translated title		The European study on the influence of risk factors on the occurrence of breast cancer in young women
Type		članek
Source		In: Bilban M, editor. Cvahtetovi dnevi javnega zdravja 2005; 2005 jun; Ljubljana. Ljubljana: Univerza v Ljubljani, Medicinska fakulteta,
Publication year		2005
Volume		str. 135-49
Language		slo
Abstract		Background: More then ten percent of patients who develop breast cancer before the age of 40 are likely to have inherited a deleterious mutation of BRCA genes. To investigate the interaction between the risk factors and genetic susceptibility the international study Case Only Study on the Interaction of Diet and Genetic Predisposition in the Occurrence of Breast Cancer in Young Women was initiated. Slovenian patients represent approximately 10% of internationally pooled data. The main objective of this paper is to present the methodology, results and conclusions of the Slovenian part of the referred international study. Methods: 312 Slovenian breast cancer patients diagnosed between 1995 and 2002 before the age of 40 were included into the study. A spcially designed questionnaire was sent to these patients. To compute the probability of BRCA mutation new software, based on Parmigiani method and named COS-software, was developed. The case-only methodology was applied to study the influence of life style risk factors on BRCA mutation penetrance. The multivariate logistic regression was used to calculate the independent effects of the individual risk factors. Results: The respondence rate of the eligible patients was 75%. 51 possibly BRCA mutated patients (cases) and 181 probably sporadic patients (controls) were analysed. Due to low, breast cancer relative risks in exposition to the lifestyle factors and small pool of Slovenian patients the analysis of complete European study are needed for more reliable results. Conclusions: Currently, the most appropriate software tool for the estimation of the magnitude of genetic susceptibility is COS-software. The well-known breast cancer risk factors seem not to influence the penetrance of BRCA mutation. The results of the study will significantly improve the primary preventive recommendation for high-risk families.
Descriptors		BREAST NEOPLASMS ADULT RISK FACTORS