Author/Editor		Pižem, J; Coer, A; Zadravec-Zaletel, L; Popović, M
Title		Survivin is a negative prognostic marker in medulloblastoma
Type		članek
Source		Neuropathol Appl Neurobiol
Vol. and No.		Letnik 31, št. 4
Publication year		2005
Volume		str. 422-8
Language		eng
Abstract		Survivin is a member of the inhibitor of apoptosis protein family, which is over-expressed in many human cancers. Our aim was to analyse survivin expression in medulloblastoma, its association with aberrant activation of the WNT (wingless) pathway and to test the prognostic significance of survivin expression. We immuno histochemically analysed survivinexpression and localization of B-catenin, a downstream mediator of the WNT pathway, in 56 cases of medulloblastoma. Survivin was detected in the nucleiof tumour cells in all cases, but the proportion of positive nuclei varied from 0.5 to 31.3%. Survivin expression tended to be higher in medulloblastomas with an aberrant activation of of the WNT pathway (nuclear localization of B-catenin), but did not correlate with histological type, age group or dissemination via cerebrospinal fluid pathways. Survivin expression and dissemination status were two independent negative prognostic variables for the overall survival of patients with medulloblastoma. In conclusion, survivin is up-regulated in medulloblastomas. It is a negative prognostic marker and a potential therapeutic target.
Descriptors		CEREBELLAR NEOPLASMS MEDULLOBLASTOMA MICROTUBULE-ASSOCIATED PROTEINS NEOPLASM PROTEINS TUMOR MARKERS, BIOLOGICAL SEX FACTORS AGE FACTORS CYTOSKELETAL PROTEINS IMMUNOCHEMISTRY PROGNOSIS SURVIVAL RATE TRANS-ACTIVATORS UP-REGULATION (PHYSIOLOGY)