Author/Editor		Ahčan, Jerneja; Čižman, Milan; Jazbec, Janez
Title		Okužbe po presaditvi krvotvornih matičnih celic pri otrocih
Translated title		Infection after hematopoietic stem-cell transplantation in children
Type		članek
Source		In: Beović B, Strle F, Čižman M, editors. Okužbe pri transplatirancih. Novosti v infektologiji. Infektološki simpozij 2005; 2005 mar; Ljubljana. Ljubljana: Slovensko zdravniško društvo, Sekcija za kemoterapijo,
Publication year		2005
Volume		str. 301-17
Language		slo
Abstract		Hematopoietic stem-cell transplantation (HSCT) is used to treat patients with advanced hematologic malignancies, solid tumors and nonmalignant conditions, including primary immunodeficiencies, hematologic diseases, and inherited metabolic disorders. Infections are a major cause of morbidity and mortality and represent the most significant barrier to both immediate and long-term survival after HSCT. Infectious complications after HSCT are somewhat predictable based on the underlying primary disease and the acquired immunodeficiencies that occur after the transplant. These immune defects and the gradual recovery of host defenses allow infections to occur in three predictable periods. Several risk factors place the HSCT recipient at increased risk for infectious complications. The approach to the HSCT patient is based on recognizing the infections that can occur during each of the at-risk periods. Diagnosis, laboratory findings, treatment and measures to prevent infectious complications, including antimicrobial prophylaxis, are described. Infectious complications and mortality of the 28 hematopoietic stem-cell transplant children who had undergone HSCT at the Pediatric clinic in Ljubljana until December 2004 are presented.
Descriptors		HEMATOPOIETIC STEM CELL TRANSPLANTATION BONE MARROW TRANSPLANTATION INFECTION CHILD BACTERIAL INFECTIONS MYCOSES VIRUS DISEASES