Author/Editor		Šuškovič, Stanislav
Title		Zdravljenje astme - ali je vse dorečeno?
Translated title		Do we know everything about asthma treatment?
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 44, št. Suppl 1
Publication year		2005
Volume		str. 155-60
Language		slo
Abstract		Asthma is a disease involving chronic airway inflammation. Inflammation is partially responsive to therapy with glucocorticoids, while the other part responds only to antileukotrienes. Consequently, combined therapy with glucocorticoids and antileukotrienes is the logical choice for many, if not most patients with asthma. Part of asthma syndrome is its airway remodeling, which is responsible for accelerated decline of the lung function, which can sometimes be as rapid as in COPD patients. Airway remodeling is responsive to therapy with glucocorticoids, and especially to the antileukotriene montelukast, but probably only in its very early phases.
Summary		Astma je bolezen s posebnim in perzistentnim vnetjem bronhijev. Vnetje bronhijev shematsko delimo na dva dela - na del, ki se odziva na glukokortikoide, in na del, ki je za glukokortikodide neodziven, je pa terapevtsko zelo odziven na antilevkotriene. Zato je astmatsko vnetje v načelu uspešno zdravljeno le s kombinacijo glukokortikoida in antilevkotriena. Astmo spremlja od njenega začetka proces vnetnega preoblikovanja bronhijev, ki povzroča pospešeni upad pljučne funkcije, ki je lahko celo primerljiv z upadom pljučne funkcije pri bolnikih s KOPB. Proces preoblikovanja bronhijev utegnemo učinkovito zavreti predvsem v začetnih fazah astme. Zato je nadvse pomembno zdraviti bolnike z novo odkrito astmo z intenzivnim protivnetnim zdravljenjem. Pri tem je treba poudariti, da pri otrocih z astmo antilevkotrien montelukast celo odpravi začetne oblike vnetnega preoblikovanja bronhijev.
Descriptors		ASTHMA GLUCOCORTICOIDS, SYNTHETIC LEUKOTRIENES BRONCHODILATOR AGENTS