Author/Editor		Žagar, Ivana
Title		Nuklearnomedicinske implikacije primene obeleženih derivata benzilgvanidina
Type		monografija
Place		Beograd
Publisher		Medicinski fakultet
Publication year		1994
Volume		str. 191
Language		ser
Abstract		The introductory chapters deal with the basic aspects of adrenomedullary structure, biochemistry and physiology. The embrionic development of tissues that may be the site of origin of various neural crest tumors is described. There follows a short review of basic and dynamic biological tests and imaging methods in diagnosis of pheochromocytoma and neuroblastoma. The development and synthesis of various labelled benzylguanidine derivatives is described. After a brief outline of the tracer cheracte ristics and the whole body imaging with 131-I-mIBG, "pitfalls" of the visualization of sympathochromafine tissues and the possibilities of various pharmacological impacts on scintigraphy are dicussed. A short review of some basic considerations of dosimetry and radionuclide tumor targeting with 131-I-mIBG is given, based on reports in most recent literature. Special emphasis is given to do simetric and methodological aspects of mIBG scintigraphy in children, as well as to some new diagnostic applications of labelled benzylguanidine in cardiology and pulmology. Whole body scintigraphy with 131-I-mIBG was performed in groups of patients with pheochromocytoma, paraganglioma, neuroblastoma, medullary thyroid carcinoma, carcinoid and malignant insulinoma. Tumor, myocardial and salivary gland uptake of mIBG were estimated semiquantitatively, according to the method of Nakajo. The uptake of 131-I-mIBG was calculated from the activity measured prior and after the application and images acquired and was expressed as percent of dose administered. Yet another the conjugated views method was used for mIBG uptake determination. Rectangular tumor regions of interest and rectangular background regions of interest around and adja cent to the lesion were used. (Abstract truncated at 2000 characters)
Descriptors		NEUROECTODERMAL TUMORS BENZYL COMPOUNDS GUANIDINES IODINE RADIOISOTOPES PHEOCHROMOCYTOMA PARAGANGLIOMA NEUROBLASTOMA THYROID NEOPLASMS CARCINOID TUMOR INSULINOMA