Author/Editor		Žagar, Ivana
Title		Kvantitativna analiza planarnog scintigrama kore nadbubrežnih žlezda u stanjima praćenim hiperaldosteronizmom
Translated title		Quantitative analysis of planary adrenocortical scintigrams in patients with hyperaldosteronism
Type		monografija
Place		Beograd
Publisher		Medicinski fakultet
Publication year		1992
Volume		str. 154
Language		ser
Abstract		The introductory chapters deal with the basic aspects of adrenal structure, biochemistry and physiology, the modalities of the use of basic and dynamic biological tests in diagnosis and differential diagnosis of hyperaldosteronism. There follows a systematic review of noninvasive imaging methods and radinuclide imaging techniques with particular emphasis on radiopharmaceuticals, technical and anatomoscintigraphic as well as possibilities of the pharmacological impact on adrenocortical scintigraphy in primary hyperaldosteronism. Adrenocortical scintigraphy with/without Dexamethasone suppression was performed in groups of patients with primary hyperaldosteronism, secondary hyperaldosteronism, low-renin essential hypertension and in patients with incidentaloma. Adrenocortical percent uptake of 75 Se-selenomethylnorcholesterol was calculated according to the method of Hawkins et al., using rectangular adrenal regions of interest and rectangular background regions of interest around and between the adrenals. The results obtained confirmed the high sensitivity (94.7%) of adrenocortical scintigraphy without Dexamethasone suppression. The sensitivity was enhanced to 100% when Dexamethasone suppression was incorporated into adrenal cortical imaging. Hence adrenocortical scintigraphy with Dexamethasone suppression is the method of choice in the differential diagnosis of zona glomerulosa hyperfunction. In aldosteronoma, the mean adrenal gland uptake values were significantly higher than those observed in the contralateral normal gland. Mean adrenal gland uptake values in primary hyperaldosteronism were also significantly higher than those found in patients with low-renin essential hypertension. (Abstract truncated at 2000 characters)
Descriptors		HYPERALDOSTERONISM SELENIUM RADIOISOTOPES