Author/Editor		Tretjak, Martin; Verovnik, Franc; Benko, Davorin; Koželj, Mirta
Title		Tissue Doppler velocities of mitral annulus and NT-proBNP in patients with heart failure
Type		članek
Source		Eur J Heart Fail
Vol. and No.		Letnik 7
Publication year		2005
Volume		str. 520-4
Language		eng
Abstract		Background. lt has been shown that pulsed wave tissue Doppler velocities of mitral annulus correlate well with left ventricular (LV) diastolic and systolic functions. It is not yet clear whether these velocities can be used to estimate left ventricular dysfunction in an unsclected population of patients with clinical signs and symptoms of heart failure (HF). Aim: To determine whether LV mitral annulus velocities measured by tissue Doppler imaging (TDl) correlate with plasma N-terminal probrain natriuretic peptide (NT-proBNP) levels in patients with HF. Methods and results: Early diastolic (Em) and systolic (Sm) TDI velocities of septal and lateral mitral annulus were measured in 50 patients with HF together with other conventional echocardiographic parameters, and compared with plasma NT-proBNP levels. Significant correlations were found between NT-proBNP level and Em velocity (r=-0.79), Sm velocity (r=-0.43), early transmitral to Em velocity ratio (r=0.38), LV end diastolic diameter (r=0.29), LV ejection fraction (r=-0.44) and tricuspid regurgitant velocity (r=0.31). In multiple regression model (R2=0.733), the Em velocity was the most important predictor of NT-proBNP level. Conclusions: Early diastolic mitral annulus velocity measured by TDI comelates strongly with plasma NT-proBNP levels, and provides a simple, accurate and reproducible echocardiographic index of heart failure.
Descriptors		HEART FAILURE, CONGESTIVE MITRAL VALVE NATRIURETIC HORMONE PEPTIDE FRAGMENTS ULTRASONOGRAPHY, DOPPLER SEX FACTORS ADULT MIDDLE AGE VENTRICULAR FUNCTION, LEFT