Author/Editor		Černič-Šuligoj, Nataša; Plazar, Nadja; Černe, Darko
Title		Circulating levels of NT-proBNP in adults without heart failure
Translated title		Serumske koncentracije NT-proBNP pri preiskovancih brez srčnega popuščanja
Type		članek
Source		Slov Kardiol
Vol. and No.		Letnik 2, št. 2
Publication year		2005
Volume		str. 106-11
Language		eng
Abstract		Background. Measurement of the concentration of amino terminal brain natriuretic peptide (NT-proBNP) represents a big clinical and diagnostic challenge in detecting and treating chronic heart failure. The reference limits depend upon age and sex. The purpose of this study was to assess normal limits for adults of various age groups. Subjects and methods. 48 adult volunteers (24 women and 24 men) aged 30 to 80 were studied. Heart failure was excluded using medical record review and echocardiography. All of the examined subjects had a normal left ventricular ejection fraction, which was determined by echocardiographic measurements. In all of them, the TEI index-a Doppler derived myocardial performance index, which combines systolic and diastolic function-had been measured. Circulating levels of NT-proBNP were also measured. Persons with high blood pressure, chronic pulmonary disease, diabetics and smokers were not excluded from the study. Results. Serum concentrations of NT-proBNP in our study were found to be from 8.1 to 378.8 ng/L, with a median of 76.0 ng/L. There was no statistically significant difference between the sexes. A striking increase of the mean values in relation to ageing (p=0.0118) was observed. Subjects older than 60 years had twice as high values as those who were younger than 60 years (p=0.0001). Hypertensive subjects had higher plasma concentrations (p=0.0004). Higher values of NT-proBNP were statistically unrelated to TEI index (p=0.3988) and to left atrial area index (p=0.1914). However, a statistically significant correlation with left ventricular mass index (p=0.0226) was found in men. Conclusions. The increase in the plasma levels of NT-proBNP is continuous and there is an overlap in the range of plasma levels in healthy subjects, subjects with asymptomatic ventricular dysfunction and those with overt heart failure. (Abstract truncated at 2000 characted).
Summary		Izhodišča. Merjenje koncentracije N-končnega propeptida natriuretičnega peptida B (NT-proBNP) predstavlja velik klinični izziv pri odkrivanju in zdravljenju srčnega popuščanja. Referenčne vrednosti so odvisne od starosti in spola. Namen naše raziskave je bil ugotoviti referenčne vrednosti za preiskovance različnih starosti. Preiskovanci in metode. V raziskavo smo vključili 48 prostovoljcev (24 žensk in 24 moških), starih od 30 do 80 let. S kliničnim in ultrazvočim pregledom smo izključili srčno popuščanje. Pri vseh smo ultrazvočno ugotovili normalen iztisni delež levega prekata. Vsem smo izmerili indeks TEI -doplersko meritev, ki združuje sistolično in diastolično funkcijo levega prekata. Izmerili smo serumsko koncentracijo NT-proBNP. Nismo izključili preiskovancev z arterijsko hipertenzijo, sladkorno boleznijo, kroničnim pljučnim obolenjem ali kadilcev. Rezultati. Izmerjene serumske koncentracije NT-proBNP v naši skupini prostovoljcev so bile od 8,1 do 378,8 ng/L, mediana vseh vrednosti je bila 76,0 ng/L. Med spoloma ni bilo statistično pomembne razlike. S starostjo vrednost NT-proBNP narašča (p =0,0118). Starejši od 60 let imajo 2,52-krat višje koncentracije kot mlajši od 60 let (p = 0,0001). Ugotovili smo višje koncentracije pri preiskovancih s hipertenzijo (p = 0,0004). Višje koncentracije NT-proBNP statistično niso bile povezane z indeksom TEI (p = 0,3988) in indeksom površine levega preddvora (p = 0,1914), ugotovili pa smo statistično pomembno povezavo z indeksom mase levega prekata pri moških (p = 0,0226). Zaključki. Naraščanje serumskih konce tracij NT-proBNP je zvezno in ni jasne meje med zdravimi, tistimi z asimptomatsko diastolično disfunkcijo levega prekata in tistimi s srčnim popuščanjem. Z našo raziskavo pri preiskovancih brez srčnega popuščanja smo ugotovi da ima v starosti precejšen delež preiskovancev zvišane serumske koncentracije NT-proBNP.
Descriptors		NATRIURETIC HORMONE ECHOCARDIOGRAPHY STROKE VOLUME VENTRICULAR FUNCTION, LEFT VENTRICULAR DYSFUNCTION, LEFT HYPERTENSION DIABETES MELLITUS SMOKING