Author/Editor		Camerini, Fulvio; Sinagra, Gianfranco; Di Lenarda, Andrea; Moretti, Michele; Mestroni, Luisa
Title		The challenge of cardiomyopathy: from clinical recognition to molecular medicine
Translated title		Izziv kardiomiopatije: od kliničnega razpoznavanja do molekularne medicine
Type		članek
Source		Slov Kardiol
Vol. and No.		Letnik 2, št. 2
Publication year		2005
Volume		str. 142-7
Language		eng
Abstract		Term cardiomyopathy, describing the non-coronary myocardial disease, was introduced nearly 50 years ago. Although first systematic approach was suggested in next years, it took another 20 years before first classsification was introduced. Substantial progress in etiology, pathogenesis, diagnostic procedures as well as therapy called for an update in the 1995. In past years, the genetics had the central role in our understanding of the cardiomyopathies. While it answered several long lasting enigmas it revealed only some of the complexity behind the cardiomy opathies. Further advances, especially in genetics, molecular biology, virology, immunology, morbid anatomy, invasive and non-invasive diagnostic technology, arrhytmology, heart failure, medical treatment, pharmacology, and cardiac surgery will help us to identify cardiomyopathies at an earlier stage and to tailor the treatment to the individual patient.
Summary		Izraz kardiomiopatija, s katerim so opisali nekoronarno bolezen miokarda, je bil prvič uporabljen pred skoraj 50 leti, čeprav je bil sistematični pristop predlagan kmalu po tem, je do nastanka prve klasifikacije poteklo 20 let. Nenehen napredek v etiologiji, patogenezi, diagnostičnih postopkih in zdravljenju je narekoval posodobitev klasifikacije v letu 1995. V zadnjih letih je k našemu razumevanju kardiomiopatij največ pripomogla genetika, ki je odgovorila na številna vprašanja, a hkrati pojasnila le del kompleksnosti kardiomiopatij. Nadaljnji napredek na področju genetike, molekularne biologije, virologije, imunologije, patologije, invazivnih in neinvazivnih diagnostičnih metod, aritmologije, srčnega popuščanja, parmakološkega zdravljenja, farmakologije in srčne kirurgije bo omogočil zgodnjejše odkrivanje kardiomiopatij in individualno zdravljenje bolnikov.
Descriptors		MYOCARDIAL DISEASES CARDIOMYOPATHY, CONGESTIVE CARDIOMYOPATHY, HYPERTROPHIC CARDIOMYOPATHY, RESTRICTIVE PHENOTYPE